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    Article

    Thymic regulatory T cells arise via two distinct developmental programs

    The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were...

    David L. Owen, Shawn A. Mahmud, Louisa E. Sjaastad, Jason B. Williams… in Nature Immunology (2019)

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    Article

    Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

    The thymus is responsible for generating a diverse yet self-tolerant pool of T cells1. Although the thymic medulla consists mostly of develo** and mature AIRE+ epithelial cells, recent evidence has suggested th...

    Corey N. Miller, Irina Proekt, Jakob von Moltke, Kristen L. Wells… in Nature (2018)