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  1. Article

    Open Access

    Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla

    The thymus’ key function in the immune system is to provide the necessary environment for the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests that the thymic stroma is co...

    Jhoanne L. Bautista, Nathan T. Cramer, Corey N. Miller… in Nature Communications (2021)

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    Article

    Thymic regulatory T cells arise via two distinct developmental programs

    The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were...

    David L. Owen, Shawn A. Mahmud, Louisa E. Sjaastad, Jason B. Williams… in Nature Immunology (2019)

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    Article

    Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

    The thymus is responsible for generating a diverse yet self-tolerant pool of T cells1. Although the thymic medulla consists mostly of develo** and mature AIRE+ epithelial cells, recent evidence has suggested th...

    Corey N. Miller, Irina Proekt, Jakob von Moltke, Kristen L. Wells… in Nature (2018)