4 Result(s)
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Irfahan Kassam
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAnalysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease
An improved understanding of etiological mechanisms in Parkinson’s disease (PD) is urgently needed because the number of affected individuals is projected to increase rapidly as populations age. We present res...
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Article
Open AccessThe effect of X-linked dosage compensation on complex trait variation
Quantitative genetics theory predicts that X-chromosome dosage compensation (DC) will have a detectable effect on the amount of genetic and therefore phenotypic trait variances at associated loci in males and ...
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Article
Open AccessBlood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH
Efficient interventions to reduce blood triglycerides are few; newer and more tolerable intervention targets are needed. Understanding the molecular mechanisms underlying blood triglyceride levels variation is...
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Article
Open AccessLong-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci
The interplay between genetic and epigenetic variation is only partially understood. One form of epigenetic variation is methylation at CpG sites, which can be measured as methylation quantitative trait loci (...
