-
Protocol
Main Existing Datasets for Open Brain Research on Humans
Recent advances in technology have made possible to quantify fine-grained individual differences at many levels, such as genetic, genomics, organ level, behavior, and clinical. The wealth of data becoming avai...
-
Article
Open AccessImpact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals
The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation i...
-
Article
Open AccessAnalysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease
An improved understanding of etiological mechanisms in Parkinson’s disease (PD) is urgently needed because the number of affected individuals is projected to increase rapidly as populations age. We present res...
-
Article
Open AccessThe effect of X-linked dosage compensation on complex trait variation
Quantitative genetics theory predicts that X-chromosome dosage compensation (DC) will have a detectable effect on the amount of genetic and therefore phenotypic trait variances at associated loci in males and ...
-
Article
Open AccessBlood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH
Efficient interventions to reduce blood triglycerides are few; newer and more tolerable intervention targets are needed. Understanding the molecular mechanisms underlying blood triglyceride levels variation is...
-
Article
Open AccessAutosomal genetic control of human gene expression does not differ across the sexes
Despite their nearly identical genomes, males and females differ in risk, incidence, prevalence, severity and age-at-onset of many diseases. Sexual dimorphism is also seen in human autosomal gene expression, a...
-
Article
Open AccessThe autosomal genetic control of sexually dimorphic traits in humans is largely the same across the sexes
There are substantial phenotypic differences between the male and female human. Several complex traits have recently been tested to see whether these phenotypic differences are explained by differences in gene...
-
Article
Open AccessLong-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci
The interplay between genetic and epigenetic variation is only partially understood. One form of epigenetic variation is methylation at CpG sites, which can be measured as methylation quantitative trait loci (...
