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  1. Article

    Open Access

    Conformational gating, dynamics and allostery in human monoacylglycerol lipase

    Inhibition of human Monoacylglycerol Lipase (hMGL) offers a novel approach for treating neurological diseases. The design of inhibitors, targeting active-inactive conformational transitions of the enzyme, can ...

    Sergiy Tyukhtenko, **aoyu Ma, Girija Rajarshi, Ioannis Karageorgos… in Scientific Reports (2020)

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  2. Article

    Open Access

    Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase

    An understanding of how conformational dynamics modulates function and catalysis of human monoacylglycerol lipase (hMGL), an important pharmaceutical target, can facilitate the development of novel ligands wit...

    Sergiy Tyukhtenko, Girija Rajarshi, Ioannis Karageorgos… in Scientific Reports (2018)

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  3. No Access

    Article

    A comparison of novel, selective fatty acid amide hydrolase (FAAH), monoacyglycerol lipase (MAGL) or dual FAAH/MAGL inhibitors to suppress acute and anticipatory nausea in rat models

    Drugs that block fatty acid amide hydrolase (FAAH, which elevates anandamide [AEA]) and drugs which block monoacylglycerol (MAGL, which elevates 2-arachidonyl glycerol [2-AG]) have promise in treating both acu...

    Linda A. Parker, Cheryl L. Limebeer, Erin M. Rock, Martin A. Sticht… in Psychopharmacology (2016)