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  1. No Access

    Protocol

    Isolation of Mitochondria-Associated ER Membranes (MAMs), Synaptic MAMs, and Glycosphingolipid Enriched Microdomains (GEMs) from Brain Tissues and Neuronal Cells

    Subcellular fractionation is a valuable procedure in cell biology to separate and purify various subcellular constituents from one another, i.e., nucleus, cytosol, membranes/organelles, and cytoskeleton. The p...

    Ida Annunziata, Jason Andrew Weesner, Alessandra d’Azzo in Mitochondrial Medicine (2021)

  2. Article

    Open Access

    MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

    Coordinated regulation of the lysosomal and autophagic systems ensures basal catabolism and normal cell physiology, and failure of either system causes disease. Here we describe an epigenetic rheostat orchestr...

    Ida Annunziata, Diantha van de Vlekkert, Elmar Wolf… in Nature Communications (2019)

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  3. Article

    Open Access

    Mitochondria-associated ER membranes (MAMs) and lysosomal storage diseases

    Lysosomal storage diseases (LSDs) comprise a large group of disorders of catabolism, mostly due to deficiency of a single glycan-cleaving hydrolase. The consequent endo-lysosomal accumulation of undigested or ...

    Ida Annunziata, Renata Sano, Alessandra d’Azzo in Cell Death & Disease (2018)

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  4. No Access

    Protocol

    Isolation of Mitochondria-Associated ER Membranes (MAMs) and Glycosphingolipid-Enriched Microdomains (GEMs) from Brain Tissues and Neuronal Cells

    Subcellular fractionation is a valuable procedure in cell biology to separate and purify various subcellular constituents from one another, i.e., nucleus, cytosol, membranes/organelles, and cytoskeleton. The p...

    Ida Annunziata, Annette Patterson, Alessandra d’Azzo in Mitochondrial Medicine (2015)

  5. No Access

    Article

    Lysosomal multienzyme complex: pros and cons of working together

    The ubiquitous distribution of lysosomes and their heterogeneous protein composition reflects the versatility of these organelles in maintaining cell homeostasis and their importance in tissue differentiation ...

    Erik J. Bonten, Ida Annunziata, Alessandra d’Azzo in Cellular and Molecular Life Sciences (2014)

  6. No Access

    Article

    Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis

    Alzheimer’s disease (AD) belongs to a category of adult neurodegenerative conditions, which are associated with intracellular and extracellular accumulation of neurotoxic protein aggregates. Understanding how ...

    Ida Annunziata, Annette Patterson, Danielle Helton, Huimin Hu… in Nature Communications (2013)