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Article
Open AccessTumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma
Patients with IDH-wild-type glioblastomas have a poor five-year survival rate along with limited treatment efficacy due to immune cell (glioma-associated microglia and macrophages) infiltration promoting tumou...
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Article
Open AccessEffects of right ventricular remodeling in chronic thromboembolic pulmonary hypertension on the outcomes of balloon pulmonary angioplasty: a 2D-speckle tracking echocardiography study
Balloon pulmonary angioplasty (BPA) improves the prognosis of chronic thromboembolic pulmonary hypertension (CTEPH). Right ventricle (RV) is an important predictor of prognosis in CTEPH patients. 2D-speckle tr...
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Article
Open AccessTrogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape
Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid tumors. Although instances of rapid tumor remissions have been observed in ...
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Article
Parameterization Method of Wind Drift Factor Based on Deep Learning in the Oil Spill Model
Oil spill prediction is critical for reducing the detrimental impact of oil spills on marine ecosystems, and the wind strongly influences the performance of oil spill models. However, the wind drift factor is ...
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Article
Smart tourism products and services design based on user experience under the background of big data
The rapid advancements in big data techniques and artificial intelligence (AI) have led to a radical transformation of the tourism industry, resulting in the development of smart tourism services and products....
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Article
Open AccessCorrection to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells
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Article
Open AccessThe anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells
Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through the loss of the wild-type (wt) TP53 tumour suppressive functions. Therefore, compounds that...
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Article
Open AccessMET fusions and splicing variants convergently define a subgroup of glioma sensitive to MET inhibitors
Our previous study has shown that PTPRZ1-MET (ZM) fusion is a viable target for MET inhibitors in gliomas. However, the diversity and prevalence of somatic MET alterations in diffuse gliomas are still elusive and...
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Article
Coupling coordination and spatial differentiation between urbanization and eco-environment: case study of Ya'an, China
The rapid urbanization of Ya'an has brought about a series of environmental issues. By referring to the physical coupling model and using the data from 2010 to 2019, this paper establishes a coupling coordinat...
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Article
Open AccessHaploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice
Rhabdomyosarcoma, the most common pediatric sarcoma, has no effective treatment for the pleomorphic subtype. Still, what triggers transformation into this aggressive phenotype remains poorly understood. Here w...
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Article
GmUGT73F4 plays important roles in enhancing seed vitality and tolerance to abiotic stresses in transgenic Arabidopsis
UDP-Glycosyltransferases (UGTs) share a common GTB (Glycosyltransferase_GTB-type Superfamily topology), typically participating in modifying small molecules and controlling many metabolic processes during plan...
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Article
GmCDPKSK5 Interacting with GmFAD2-1B Participates in Regulation of Seed Development in Soybean Under High Temperature and Humidity Stress
Soybean seeds are easily affected by high temperature and humidity (HTH) stress during growth and development period, which usually results in serious seed deterioration in field before harvest. In our previou...
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Article
Open AccessDiagnostic value of miRNA expression and right ventricular echocardiographic functional parameters for chronic thromboembolic pulmonary hypertension with right ventricular dysfunction and injury
We aimed to establish the relationships between the expression of microRNAs (miRNAs) and echocardiographic right ventricular (RV) function parameters, and to explore the effectiveness and clinical value of miR...
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Article
MiR-361-3p alleviates cerebral ischemia–reperfusion injury by targeting NACC1 through the PINK1/Parkin pathway
Ischemic stroke is a nervous system disease with high rates of disability and mortality. MicroRNAs have been reported to modulate cerebral ischemia. The current study aimed to study the role of miR-361-3p in c...
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Article
Mechanically activated calcium carbonate and zero-valent iron composites for one-step treatment of multiple pollutants
The growing presences of conventional and emerging contaminants make the wastewater treatment increasingly difficult and expensive on a global scale. ZVI tends to be an expectable material for the detoxificati...
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Article
Open AccessInterstitial boron-triggered electron-deficient Os aerogels for enhanced pH-universal hydrogen evolution
Develo** high-performance electrocatalysts for hydrogen evolution reaction (HER) is crucial for sustainable hydrogen production, yet still challenging. Here, we report boron-modulated osmium (B-Os) aerogels ...
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Chapter
Observation and Policy Recommendations for Industrial Relocation under the Belt and Road Initiative — From the perspective of international industrial-capacity cooperation
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Chapter and Conference Paper
Study on Shape Coding Identification of Polygonal Knob
Shape coding is coded with different shapes so that the controllers could be de-signed with different shapes and patterns for different functions. It is widely used in industrial product design and man-machine...
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Article
Open AccessHigh doses of dexamethasone induce endoplasmic reticulum stress-mediated apoptosis by promoting calcium ion influx-dependent CHOP expression in osteoblasts
The long-term use of dexamethasone (Dex), a well-known immunosuppressant, leads to an imbalance in bone metabolism and rapid decline of bone mineral density due to apoptosis of osteoblasts. The molecular mecha...
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Article
Increased proportion of Th17/Treg cells at the new diagnosed stage of chronic immune thrombocytopenia in pediatrics: the pilot study from a multi-center
Chronic immune thrombocytopenia (CITP) is an autoimmune disease with many immune dysfunctions, including T helper type 17 cell (Th17)/regulatory T cells (Tregs) imbalance. Low quality of life and side effects ...
