12 Result(s)

Article

Fine map** of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder

A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10⁻⁷), and stronger evidence when t...

H J Williams, N Norton, S Dwyer, V Moskvina, I Nikolov, L Carroll… in Molecular Psychiatry (2011)

Article

Strong genetic evidence for a selective influence of GABA_A receptors on a component of the bipolar disorder phenotype

Despite compelling evidence for a major genetic contribution to risk of bipolar mood disorder, conclusive evidence implicating specific genes or pathophysiological systems has proved elusive. In part this is l...

N Craddock, L Jones, I R Jones, G Kirov, E K Green, D Grozeva… in Molecular Psychiatry (2010)

Article

A genome-wide association study in 574 schizophrenia trios using DNA pooling

The cost of genome-wide association (GWA) studies can be prohibitively high when large samples are genotyped. We conducted a GWA study on schizophrenia (SZ) and to reduce the cost, we used DNA pooling. We used...

G Kirov, I Zaharieva, L Georgieva, V Moskvina, I Nikolov, S Cichon… in Molecular Psychiatry (2009)

Article

Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk

Genome-wide association (GWAS) analyses have identified susceptibility loci for many diseases, but most risk for any complex disorder remains unattributed. There is therefore scope for complementary approaches...

V Moskvina, N Craddock, P Holmans, I Nikolov, J S Pahwa, E Green… in Molecular Psychiatry (2009)

Article

Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2

We and others have previously reported linkage to schizophrenia on chromosome 10q25–q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide p...

M C O'Donovan, N Norton, H Williams, T Peirce, V Moskvina… in Molecular Psychiatry (2009)

Article

Stage 2 of the Wellcome Trust UK–Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16–q21, 4q12–q21, 9p21, 10p14–p12 and 18q22

Bipolar affective disorder (BPAD) is a common psychiatric disorder with complex genetic aetiology. We have undertaken a genome-wide scan in one of the largest samples of bipolar affected sibling pairs (ASPs) u...

D Lambert, F Middle, M L Hamshere, R Segurado, R Raybould, A Corvin… in Molecular Psychiatry (2005)

Article

Association between PRODH and schizophrenia is not confirmed

H J Williams, N Williams, G Spurlock, N Norton, D Ivanov… in Molecular Psychiatry (2003)

Article

Mutation screening and LD map** in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach

We examined whether variation within six genes from the VCFS critical region at 22q11 (DGSC, Stk22A1, DGSI, Gscl, Slc25A1 and Znf74) confers susceptibility to schizophrenia. We screened the exons and flanking int...

N M Williams, G Spurlock, N Norton, H J Williams, M L Hamshere… in Molecular Psychiatry (2002)