16 Result(s)

Article

Association between PRODH and schizophrenia is not confirmed

H J Williams, N Williams, G Spurlock, N Norton, D Ivanov… in Molecular Psychiatry (2003)

Article

Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia

Recently, it has been reported that genetic variants around the gene neuregulin 1 are associated with schizophrenia in an Icelandic sample. Of particular interest was the presence of a single-risk haplotype th...

N M Williams, A Preece, G Spurlock, N Norton, H J Williams… in Molecular Psychiatry (2003)

Article

Mutation screening and LD map** in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach

We examined whether variation within six genes from the VCFS critical region at 22q11 (DGSC, Stk22A1, DGSI, Gscl, Slc25A1 and Znf74) confers susceptibility to schizophrenia. We screened the exons and flanking int...

N M Williams, G Spurlock, N Norton, H J Williams, M L Hamshere… in Molecular Psychiatry (2002)

Article

Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor

The glutamatergic system is the major excitatory neurotransmitter system in the CNS. Glutamate receptors, and in particular N-methyl-D-aspartate (NMDA) receptors, have been proposed as mediators of many common...

N M Williams, T Bowen, G Spurlock, N Norton, H J Williams… in Molecular Psychiatry (2002)

Article

Characterisation, mutation detection, and association analysis of alternative promoters and 5′ UTRs of the human dopamine D3 receptor gene in schizophrenia

The dopamine D₃ receptor gene (DRD3) is a candidate for a number of psychiatric conditions including schizophrenia, bipolar disorder and alcohol and drug abuse. Previous studies have reported associations between...

R J Anney, M I Rees, E Bryan, G Spurlock, N Williams, N Norton… in Molecular Psychiatry (2002)

Article

Mutation screening of the KCNN3 gene reveals a rare frameshift mutation

T Bowen, N Williams, N Norton, G Spurlock, O H Wittekindt… in Molecular Psychiatry (2001)

Article

The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia

Neurotensin and its high affinity receptor (NTSR1) localise within dopaminergic neurones in the mesocortical, mesolimbic and nigrostriatal systems^{1, 2, 3, 4, 5} and it is now clear that neurotensin can selectively...

J Austin, P Buckland, A G Cardno, N Williams, G Spurlock… in Molecular Psychiatry (2000)

Article

Comparative sequencing of the proneurotensin gene and association studies in schizophrenia

Neurotensin (NT) is an endogenous tridecapetide¹ cleaved from a precursor proneurotensin/ proneuromedin protein. NT localises within dopaminergic neurones in the mesocortical, mesolimbic and nigrostriatal systems

J Austin, B Hoogendoorn, P Buckland, G Speight, A Cardno, T Bowen… in Molecular Psychiatry (2000)

Article

Autosome search for schizophrenia susceptibility genes in multiply affected families

We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were dis...

M I Rees, I Fenton, N M Williams, P Holmans, N Norton, A Cardno… in Molecular Psychiatry (1999)

Article

Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia

A recent study has suggested that a polymorphism in the hKCa3 potassium channel may be associated with raised susceptibility to schizophrenia.¹ Despite its modest statistical significance, the study¹ is intriguin...

T Bowen, C A Guy, N Craddock, A G Cardno, N M Williams, G Spurlock… in Molecular Psychiatry (1998)

Article

A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia

We performed a meta-analysis of over 30 case-control studies of association between schizophrenia and a bi-allelic, BalI polymorphism in exon 1 of the dopamine D3 receptor gene. We observed a significant excess o...

J Williams, G Spurlock, P Holmans, R Mant, K Murphy, L Jones… in Molecular Psychiatry (1998)

Article

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT_2A receptor gene and response to clozapine

Clozapine is a potent atypical antipsychotic which binds to a variety of neurotransmitter receptors including serotonin (5-HT) receptors. However, the precise neurochemical site of clozapine's therapeutic acti...

M J Arranz, J Munro, M J Owen, G Spurlock, P C Sham, J Zhao… in Molecular Psychiatry (1998)

Article

A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter

Several studies have shown an association between schizophrenia and the C allele of a T-C polymorphism at nucleotide 102 and the 5HT2A receptor gene. In the present study we observed this association in a samp...

G Spurlock, A Heils, P Holmans, J Williams, U M D'Souza, A Cardno… in Molecular Psychiatry (1998)

Article

No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia

Several recent studies have suggested that expanded CAG repeats may contribute to the genetic transmission of bipolar disorder and schizophrenia. In all known disorders associated with expanded CAG repeats, th...

A L Jones, F Middle, C Guy, G Spurlock, N J Cairns, P McGuffin… in Molecular Psychiatry (1997)

Chapter and Conference Paper

Endogenous Na⁺, K⁺-ATPase Inhibitors

Evidence began to mount during the 1960s for the existence of an endogenous regulator of sodium transport. De Wardener demonstrated that extracellular fluid volume (ECFV) expansion by saline infusion in dogs p...

M. D. Lewis, S. E. Thomas, J. M. Kendall, G. Spurlock… in Neuroendocrine Perspectives (1989)