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Article
Open AccessEffectiveness and safety of adalimumab in patients with intestinal Behçet’s disease: a real-world prospective observational study in South Korea
Intestinal Behçet’s disease (BD) is characterized by typical gastrointestinal ulcers in patients with BD followed by complications such as bleeding, perforation and fistula. Biologic agents are currently under...
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Article
Open AccessClinical outcomes of esophageal granular cell tumors with different endoscopic resection methods
Esophageal granular cell tumors (GCTs), the second most common subepithelial tumors (SETs) of the esophagus, are potentially malignant with no definite management guidelines available. We retrospectively enrol...
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Article
Open Access14-3-3γ haploinsufficiency leads to altered dopamine pathway and Parkinson’s disease-like motor incoordination in mice
The 14-3-3 protein family with seven isoforms found in mammals is widely expressed in the brain and plays various roles in cellular processes. Several studies have reported that 14-3-3γ, one of the 14-3-3 prot...
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Article
Correction to: Long‑term outcomes and surveillance timing of patients with large non‑pedunculated colorectal polyps with histologically incomplete resection in endoscopic resection
A correction to this paper has been published: https://doi.org/10.1007/s00464-021-08454-6
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Article
Open AccessOptimal ICG dosage of preoperative colonoscopic tattooing for fluorescence-guided laparoscopic colorectal surgery
Indocyanine green (ICG) is a multifunctional dye used in tumor localization, tissue perfusion, and lymph node (LN) map** during fluorescence-guided laparoscopic colorectal surgery.
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Article
Open AccessTrophoblast glycoprotein is a new candidate gene for Parkinson’s disease
Parkinson’s disease (PD) is a movement disorder caused by progressive degeneration of the midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta (SNc). Despite intense research efforts over ...
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Article
Open AccessHuman kidney organoids reveal the role of glutathione in Fabry disease
Fabry disease is an X-linked lysosomal storage disease caused by a mutation in the galactosidase alpha (GLA) gene. Despite advances in therapeutic technologies, the lack of humanized experimental models of Fab...
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Article
Open AccessAbsent or impaired rectoanal inhibitory reflex as a diagnostic factor for high-grade (grade III–V) rectal prolapse: a retrospective study
Clinically diagnosing high-grade (III–V) rectal prolapse might be difficult, and the prolapse can often be overlooked. Even though defecography is the significant diagnostic tool for rectal prolapse, it is not...
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Article
Open AccessSevere hypoglycemia and the risk of end stage renal disease in type 2 diabetes
We investigated the association between the incidence of severe hypoglycemia and the risk of end-stage renal disease (ESRD) in patients with type 2 diabetes. Baseline and follow-up data for 988,333 participant...
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Article
Open AccessCorrection to: Graft immaturity and safety concerns in transplanted human kidney organoids
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessClinical outcomes of iatrogenic upper gastrointestinal endoscopic perforation: a 10-year study
Upper gastrointestinal endoscopic examination is a relatively safe procedure; however, all endoscopic procedures are invasive and are associated with a risk of iatrogenic perforation. To evaluate clinical outc...
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Article
Open AccessPossible indication of endoscopic resection in undifferentiated early gastric cancer
Endoscopic resection for early gastric cancer (EGC) without lymph node metastasis may be a valuable treatment option. To date, endoscopic resection for undifferentiated EGC is being investigated. We evaluated ...
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Article
Open AccessGraft immaturity and safety concerns in transplanted human kidney organoids
For chronic kidney disease, regeneration of lost nephrons with human kidney organoids derived from induced pluripotent stem (iPS) cells is proposed to be an attractive potential therapeutic option. It remains ...
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Article
Open AccessRisk factors for delayed bleeding by onset time after endoscopic submucosal dissection for gastric neoplasm
Post-endoscopic submucosal dissection bleeding (PEB) is one of the important complications after endoscopic submucosal dissection (ESD), but still difficult to predict. The present study aimed to identify sign...
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Article
Open AccessCalcimimetic restores diabetic peripheral neuropathy by ameliorating apoptosis and improving autophagy
Decreased AMPK-eNOS bioavailability mediates the development of diabetic peripheral neuropathy (DPN) through increased apoptosis and decreased autophagy activity in relation to oxidative stress. Schwann cells ...
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Article
Open AccessCinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy
Apoptosis and autophagy are harmoniously regulated biological processes for maintaining tissue homeostasis. AMP-activated protein kinase (AMPK) functions as a metabolic sensor to coordinate cellular survival a...
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Article
Open AccessClinical outcomes of endoscopic submucosa dissection for high-grade dysplasia from endoscopic forceps biopsy
Although the Vienna Classification recommends endoscopic resection for gastric high-grade dysplasia (HGD), many resected lesions are diagnosed as gastric cancer after endoscopic resection. This study aims to e...
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Article
Open AccessRetraction Note to: Chronic NMDA administration to rats increases brain pro-apoptotic factors while decreasing anti-Apoptotic factors and causes cell death
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Article
Open AccessRetraction Note to: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
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Article
Open AccessConditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons
Reduction of mitochondrial complex I activity is one of the major hypotheses for dopaminergic neuron death in Parkinson’s disease. However, reduction of complex I activity in all cells or selectively in dopami...
