70 Result(s)
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Richard D. Palmiter
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Article
Open AccessDevelopment of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The func...
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Open AccessParabrachial tachykinin1-expressing neurons involved in state-dependent breathing control
Breathing is regulated automatically by neural circuits in the medulla to maintain homeostasis, but breathing is also modified by behavior and emotion. Mice have rapid breathing patterns that are unique to the...
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Open AccessTopographic representation of current and future threats in the mouse nociceptive amygdala
Adaptive behaviors arise from an integration of current sensory context and internal representations of past experiences. The central amygdala (CeA) is positioned as a key integrator of cognitive and affective...
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Open AccessReciprocal control of obesity and anxiety–depressive disorder via a GABA and serotonin neural circuit
The high comorbidity between obesity and mental disorders, such as depression and anxiety, often exacerbates metabolic and neurological symptoms significantly. However, neural mechanisms that underlie reciproc...
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Intercalated amygdala clusters orchestrate a switch in fear state
Adaptive behaviour necessitates the formation of memories for fearful events, but also that these memories can be extinguished. Effective extinction prevents excessive and persistent reactions to perceived thr...
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Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake
Excessive alcohol drinking has been shown to modify brain circuitry to predispose individuals for future alcohol abuse. Previous studies have implicated the central nucleus of the amygdala (CeA) as an importan...
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Open AccessSatb2 neurons in the parabrachial nucleus mediate taste perception
The neural circuitry mediating taste has been mapped out from the periphery to the cortex, but genetic identity of taste-responsive neurons has remained elusive. Here, we describe a population of neurons in th...
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Open AccessOrgan-specific, multimodal, wireless optoelectronics for high-throughput phenoty** of peripheral neural pathways
The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effe...
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Open AccessA new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis
Interleukin-6 (IL-6) is a pleiotropic cytokine that controls numerous physiological processes both in basal and neuroinflammatory conditions, including the inflammatory response to experimental autoimmune ence...
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Open AccessLoss of glutamate signaling from the thalamus to dorsal striatum impairs motor function and slows the execution of learned behaviors
Parkinson’s disease (PD) is primarily associated with the degeneration of midbrain dopamine neurons, but it is now appreciated that pathological processes like Lewy-body inclusions and cell loss affect several...
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Encoding of danger by parabrachial CGRP neurons
Animals must respond to various threats to survive. Neurons that express calcitonin gene-related peptide in the parabrachial nucleus (CGRPPBN neurons) relay sensory signals that contribute to satiation and pain-i...
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Open AccessOxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake
Brain regions that regulate fluid satiation are not well characterized, yet are essential for understanding fluid homeostasis. We found that oxytocin-receptor-expressing neurons in the parabrachial nucleus of ...
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Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus
Most cancer patients experience loss of appetite and feelings of illness, which contribute to cancer-related deaths and morbidity. The authors demonstrate that, in mice, activation of a subset of neurons in th...
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Open AccessConditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons
Reduction of mitochondrial complex I activity is one of the major hypotheses for dopaminergic neuron death in Parkinson’s disease. However, reduction of complex I activity in all cells or selectively in dopami...
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Bone-derived hormone suppresses appetite
The glycoprotein lipocalin 2 is released from the bones of mice in a nutrient-dependent manner and binds to receptors in the brain to suppress appetite. This is the first example of bone-derived signals mediat...
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HSD2 neurons in the hindbrain drive sodium appetite
Activation of putative aldosterone-sensitive neurons in the hindbrain drives mice to drink sodium solutions, and this appetite is distinct from thirst and hunger. These neurons are critical for animals to full...
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Fast-acting neurons that suppress appetite
Recent studies reveal several groups of neurons that become activated upon anticipation or consumption of meals. These neurons constitute key components of the complex feedback system that prevents continuous ...
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Open AccessGenetically and functionally defined NTS to PBN brain circuits mediating anorexia
The central nervous system controls food consumption to maintain metabolic homoeostasis. In response to a meal, visceral signals from the gut activate neurons in the nucleus of the solitary tract (NTS) via the...
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Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state
Starving animals are less likely to defend their home territory and more likely to engage in risky foraging behaviors. This work describes a circuit involving hypothalamic AgRP neurons projecting to neurons in...
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The paraventricular thalamus controls a central amygdala fear circuit
Inhibiting projections from the paraventricular nucleus of the thalamus to a specific division of the amygdala prevents fear conditioning in mice, indicating an important role for the thalamus–amygdala circuit...
