17 Result(s)

Article

Liquid-based cytology specimens for next-generation sequencing in lung adenocarcinoma: challenges and evaluation of targeted therapy

To explore challenges of liquid-based cytology (LBC) specimens for next-generation sequencing (NGS) in lung adenocarcinoma and evaluate the efficacy of targeted therapy.

**aoyue **ao, ZiHan Sun, Shuo Liang, Weihua Li, HuiQin Guo, Huan Zhao… in BMC Cancer (2024)

Article

IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells

Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang… in Leukemia (2023)

Article

SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal

A novel recombinant SIRPα-Fc fusion protein, IMM01, was constructed and produced using an in-house developed CHO-K1 cell expression system, and the anti-tumor mechanism of IMM01 targeting the CD47-SIRPα pathwa...

Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo… in Journal of Hematology & Oncology (2022)

Article

LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer

Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may be associated with the proliferation and metastasis of GC. It has been reporte...

Dan-Dan Shen, **g-Ru Pang, Ya-** Bi, Long-Fei Zhao, Yin-Rui Li… in Molecular Cancer (2022)

Article

Functions, mechanisms, and therapeutic implications of METTL14 in human cancer

RNA modification plays a crucial role in many biological functions, and its abnormal regulation is associated with the progression of cancer. Among them, N⁶-methyladenine (m⁶A) is the most abundant RNA modificati...

Qian Guan, Huiran Lin, Lei Miao, Huiqin Guo… in Journal of Hematology & Oncology (2022)

Article

Comparative metabolome analysis of serum changes in sheep under overgrazing or light grazing conditions

Overgrazing is a primary contributor to severe reduction in forage quality and production in Inner Mongolia, leading to extensive ecosystem degradation, sheep health impairment and growth performance reduction...

Jize Zhang, Yang Gao, Huiqin Guo, Yong Ding, Weibo Ren in BMC Veterinary Research (2019)

Article

Identification and profiling of microRNAs responsive to cadmium toxicity in hepatopancreas of the freshwater crab Sinopotamon henanense

Cadmium (Cd) is a ubiquitous environmental toxicant for aquatic animals. The freshwater crab, Sinopotamon henanense (S. henanense), is a useful model for monitoring Cd exposure since it is widely distributed in s...

Peng Xu, Huiqin Guo, Huihui Wang, Yuxin **e, Shao Chin Lee, Ming Liu… in Hereditas (2019)

Article

Hepatic transcriptome profile of sheep (Ovis aries) in response to overgrazing: novel genes and pathways revealed

Overgrazing is a major factor that causes steppe degradation in Inner Mongolian, resulting in extensive ecosystem damage. Scarcity of grass means sheep are smaller and therefore mutton and cashmere production ...

Weibo Ren, Warwick Badgery, Yong Ding, Huiqin Guo, Yang Gao, Jize Zhang in BMC Genetics (2019)

Article

De novo transcriptomic profiling of the clonal Leymus chinensis response to long-term overgrazing-induced memory

Sheepgrass (Leymus chinensis) is one of the dominant grass species present on typical steppes of the Inner Mongolia Plateau. However, L. chinensis has developed a dwarfing phenotype in response to the stressful h...

Weibo Ren, **angyang Hou, Zinian Wu, Lingqi Kong, Huiqin Guo… in Scientific Reports (2018)

Article

Potential molecular mechanisms of overgrazing-induced dwarfism in sheepgrass (Leymus chinensis) analyzed using proteomic data

This study was designed to reveal potential molecular mechanisms of long-term overgrazing-induced dwarfism in sheepgrass (Leymus chinensis).

Weibo Ren, Jihong **e, **angyang Hou, **liang Li, Huiqin Guo… in BMC Plant Biology (2018)

Article

Overgrazing induces alterations in the hepatic proteome of sheep (Ovis aries): an iTRAQ-based quantitative proteomic analysis

The degradation of the steppe of Inner Mongolia, due to overgrazing, has resulted in ecosystem damage as well as extensive reductions in sheep production. The growth performance of sheep is greatly reduced bec...

Weibo Ren, **angyang Hou, Yuqing Wang, Warwick Badgery, **liang Li… in Proteome Science (2017)

Article

A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity

A novel hirudin isoform 3 mimetic peptide, named peptide S2, has been prepared by introduction of a stearic acid modification. Peptide S2 exhibited superior inhibitory activity to hirulog-1 (Bivariludin) and s...

Zhuguo Liu, Zheng Yu, Yuanyuan Huang, Yan Zhang, Guozhu Han, **an Li… in Scientific Reports (2015)

Article

The reversal of antineoplastic drug resistance in cancer cells by β-elemene

Multidrug resistance (MDR), defined as the resistance of cancer cells to compounds with diverse structures and mechanisms of actions, significantly limits the efficacy of antitumor drugs. A major mechanism tha...

Guan-Nan Zhang, Charles R. Ashby Jr., Yun-Kai Zhang… in Chinese Journal of Cancer (2015)

Article

Next-generation sequencing for molecular diagnosis of lung adenocarcinoma specimens obtained by fine needle aspiration cytology

Identification of multi-gene variations has led to the development of new targeted therapies in lung adenocarcinoma patients and identification of an appropriate patient population with a reliable screening me...

Tian Qiu, Huiqin Guo, Huan Zhao, Luhua Wang, Zhihui Zhang in Scientific Reports (2015)