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  1. Article

    Open Access

    SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

    SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (SG614) with the original (SD614). We report here pseudoviruses ca...

    Lizhou Zhang, Cody B. Jackson, Huihui Mou, Amrita Ojha… in Nature Communications (2020)

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  2. No Access

    Article

    A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo

    Widespread use of gene therapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges that control transgene expression without the requirement of additional protein com...

    Guocai Zhong, Haimin Wang, Wenhui He, Yujun Li, Huihui Mou… in Nature Biotechnology (2020)

  3. Protocol

    Identification of Protein Receptors for Coronaviruses by Mass Spectrometry

    As obligate intracellular parasites, viruses need to cross the plasma membrane and deliver their genome inside the cell. This step is initiated by the recognition of receptors present on the host cell surface....

    V. Stalin Raj, Mart M. Lamers, Saskia L. Smits, Jeroen A. A. Demmers… in Coronaviruses (2015)

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  4. Article

    Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

    Human coronavirus-EMC (hCoV-EMC) is a new coronavirus that has killed around half of the few humans infected so far; this study now identifies DPP4 as the receptor that this virus uses to infect cells.

    V. Stalin Raj, Huihui Mou, Saskia L. Smits, Dick H. W. Dekkers, Marcel A. Müller… in Nature (2013)

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