12 Result(s)
within
Hui-** Hsu
Life Sciences
Cell Biology
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Article
Characterization and phylogenetic analysis of a thermostable N-carbamoyl-l-amino acid amidohydrolase from Bacillus kaustophilus CCRC11223
A thermostable N-carbamoyl-l-amino acid amidohydrolase (l-N-carbamoylase) gene composed of an 1,230-bp ORF encoding a 44.3-kDa protein was cloned from the thermophile Bacillus kaustophilus CCRC11223. This l-N-car...
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Protocol
A Hierarchical Protein Folding Scheme Based on the Building Block Folding Model
The building block protein folding model states that the native protein structure is the product of a combinatorial assembly of relatively structurally independent contiguous parts of the protein that possess ...
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Protocol
Quantitative Trait Locus (QTL) Map** in Aging Systems
Understanding the genetic basis of the effects of aging on the decline in the immune response is an enormous undertaking. The most prominent age-related change in the immune system is thymic involution. This c...
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Open AccessThe adaptor protein SH2B1β reduces hydrogen peroxide-induced cell death in PC12 cells and hippocampal neurons
SH2B1β is a signaling adaptor protein that has been shown to promote neuronal differentiation in PC12 cells and is necessary for the survival of sympathetic neurons. However, the mechanism by which SH2B1β may ...
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Article
Overexpression of ornithine decarboxylase suppresses thapsigargin-induced apoptosis
Ornithine decarboxylase (ODC), the key enzyme of polyamine biosynthesis, has paradoxical roles in apoptosis. Our published papers show overexpression of ODC prevents the apoptosis induced by many cytotoxic dru...
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Article
Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling
The schizophrenia susceptibility gene, Rgs4, is one of the most intensively studied regulators of G-protein signaling members, well known to be fundamental in regulating neurotransmission. However, little is know...
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SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
The serine/threonine kinase Akt plays a central role in cell proliferation, survival and metabolism, and its hyperactivation is linked to cancer ...
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Author Correction: SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00686-x
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Article
UHRF1: a novel metabolic guardian restricting AMPK activity
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Open AccessMicroRNA-145-5p modulates Krüppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma
In several human cancers, Krüppel-like factor 5 (KLF5), a zinc finger transcription factor, can contribute to both tumor progression or suppression; however, the precise role of KLF5 in nasopharyngeal carcinom...
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Article
Open AccessLoss of fragile WWOX gene leads to senescence escape and genome instability
Induction of DNA damage response (DDR) to ensure accurate duplication of genetic information is crucial for maintaining genome integrity during DNA replication. Cellular senescence is a DDR mechanism that prev...
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Open AccessThe in vitro and in vivo depigmentation activity of coenzyme Q0, a major quinone derivative from Antrodia camphorata, through autophagy induction in human melanocytes and keratinocytes
Coenzyme Q0 (CoQ0), a novel quinone derivative of Antrodia camphorata, has been utilized as a therapeutic agent (including antioxidant, anti-inflammatory, antiangiogenic, antiatherosclerotic, and anticancer agent...
