![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessGut microbiota affects the estrus return of sows by regulating the metabolism of sex steroid hormones
Sex hormones play important roles in the estrus return of post-weaning sows. Previous studies have demonstrated a complex and bi-directional regulation between sex hormones and gut microbiota. However, the ext...
-
Article
Open AccessAuthor Correction: Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling
-
Article
Open AccessQuartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling
Certified RNA reference materials are indispensable for assessing the reliability of RNA sequencing to detect intrinsically small biological differences in clinical settings, such as molecular subty** of dis...
-
Article
Open AccessMulti-omics data integration using ratio-based quantitative profiling with Quartet reference materials
Characterization and integration of the genome, epigenome, transcriptome, proteome and metabolome of different datasets is difficult owing to a lack of ground truth. Here we develop and characterize suites of ...
-
Article
The Pseudogene BMEA_B0173 Deficiency in Brucella melitensis Contributes to M-epitope Formation and Potentiates Virulence in a Mice Infection Model
It is widely acknowledged that pseudogenes play important roles in bacterial diversification and evolution and participate in gene regulation and RNA interference (RNAi). However, the function of most pseudoge...
-
Article
Open AccessIdentification of the sesquiterpene synthase AcTPS1 and high production of (–)-germacrene D in metabolically engineered Saccharomyces cerevisiae
The sesquiterpene germacrene D is a highly promising product due to its wide variety of insecticidal activities and ability to serve as a precursor for many other sesquiterpenes. Biosynthesis of high value com...
-
Article
Intelligent bio-assembly imaging-guided platform for real-time bacteria sterilizing and infectious therapy
Bacterial infection is rising as a threatening health issue. Because of the present delay in early diagnosis of bacterial diseases as well as the abuse of antibiotics, it has become a vital issue in the develo...
-
Article
Metabolic pathway analysis of walnut endophytic bacterium Bacillus subtilis HB1310 related to lipid production from fermentation of cotton stalk hydrolysate based on genome sequencing
In this study, genome sequencing and metabolic analysis were used to identify and verify the key metabolic pathways for glucose and xylose utilization and fatty acid synthesis in the walnut endophytic bacteriu...
-
Article
Deep sequencing of the Sanghuangporus vaninii transcriptome reveals dynamic landscapes of candidate genes involved in the biosynthesis of active compounds
The medicinal fungus Sanghuang produces diverse bioactive compounds and is widely used in Asian countries. However, little is known about the genes and pathways involved in the biosynthesis of these active compou...
-
Article
Strategies for Discovering New Antibiotics from Bacteria in the Post-Genomic Era
New antibiotics are urgently required in clinical treatment and agriculture with the development of antimicrobial resistance. However, products discovered by repeating previous strategies are either not antibi...
-
Article
Open AccessEnhanced biohydrogen production from cotton stalk hydrolysate of Enterobacter cloacae WL1318 by overexpression of the formate hydrogen lyase activator gene
Biohydrogen production from lignocellulose has become an important hydrogen production method due to its diversity, renewability, and cheapness. Overexpression of the formate hydrogen lyase activator (fhlA) gene ...
-
Article
Open AccessA simple method for in vitro preparation of natural killer cells from cord blood
Cord Blood (CB) has been considered a promising source of natural killer (NK) cells for cellular immunotherapy. However, it is difficult to expand the large numbers of highly pure NK cells from CB without cell...
-
Article
Bacillus subtilis Spore Surface Display of Haloalkane Dehalogenase DhaA
The haloalkane dehalogenase DhaA can degrade sulfur mustard (2,2′-dichlorethyl sulfide; also known by its military designation HD) in a rapid and environmentally safe manner. However, DhaA is sensitive to temp...
-
Article
New two-component regulatory system required for the constitutive expression of bph operon in Cupriavidus basilensis WS
Cupriavidus basilensis WS degrades diphenyl ether (DE) and its lower brominated derivatives using enzymes encoded by the bph operon. However, it is not yet known under what circumstances bph genes are expressed a...
-
Article
Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling
Nat. Biotechnol. 10.1038/nbt.4183; corrected online 31 July 2018 In the version of this article initially published online, the text “Beth Israel Deaconess Medical Center/Dana Farber Cancer Institute (BIDMC/DF...
-
Article
Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling
Systematic evaluation of library preparation methods for small RNA-seq identifies reproducible and accurate methods.
-
Article
Biohydrogen production from fermentation of cotton stalk hydrolysate by Klebsiella sp. WL1316 newly isolated from wild carp (Cyprinus carpio L.) of the Tarim River basin
A new hydrogen-producing bacterium was isolated from the intestine of wild carp (Cyprinus carpio L.) of the Tarim River Basin. The isolate was identified as Klebsiella sp. based on 16S rDNA gene sequencing and ex...
-
Article
Co-cultured the MSCs and cardiomyocytes can promote the growth of cardiomyocytes
Recently, the incidence of myocardial infarction has been increasing annually. Now cell therapy is a major new strategy in the treatment of this public health challenge. Most recently, evidences showed that MS...
-
Article
Design of dual metal ions/dual amino acids integrated photoluminescent logic gate by high-molecular weight protein-localized Au nanoclusters
Proteins are excellent templates and stabilizers for Au nanoclusters (NCs) because of their abundant thiol groups and unique internal environments. However, high-molecular weight (MW) proteins with special qua...
-
Article
Rapid and multimodal in vivo bioimaging of cancer cells through in situ biosynthesis of Zn&Fe nanoclusters
Early diagnosis remains highly important for efficient cancer treatment, and hence, there is significant interest in the development of effective imaging strategies. This work reports a new multimodal bioimagi...