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Article
Germline AIP variants in sporadic young acromegaly and pituitary gigantism: clinical and genetic insights from a Han Chinese cohort
Variants in the Aryl hydrocarbon receptor-interacting protein (AIP) gene have been identified in sporadic acromegaly and pituitary gigantism, especially in young patients, with a predisposition to aggressive clin...
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Article
Open AccessAuthor Correction: Identification of recurrent USP48 and BRAF mutations in Cushing’s disease
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Article
The recovery time of hypothalamic-pituitary-adrenal axis after curative surgery in Cushing’s disease and its related factor
Patients with Cushing’s disease (CD) experienced transient central adrenal insufficiency (CAI) after successful surgery. However, the reported recovery time of hypothalamic-pituitary-adrenal (HPA) axis varied ...
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Article
The hypothalamic-pituitary-gonad axis in male Cushing’s disease before and after curative surgery
Gonadal and sexual disturbances are commonly encountered in patients with Cushing’s disease. Nevertheless, the prevalence of hypogonadism in male Cushing’s disease, the risk factors as well as the recovery tim...
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Article
Radiomics analysis allows for precise prediction of silent corticotroph adenoma among non-functioning pituitary adenomas
To predict silent corticotroph adenomas (SCAs) among non-functioning pituitary adenomas preoperatively using noninvasive radiomics.
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Article
Open AccessEstablishment of reference intervals of monomeric prolactin to identify macroprolactinemia in Chinese patients with increased total prolactin
Macroprolactin is responsible for pseudohyperprolactinemia and is a common pitfall of the prolactin immunoassay. We aimed to determine the frequency of macroprolactinemia in Chinese hyperprolactinemic patients...
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Article
Machine learning in predicting early remission in patients after surgical treatment of acromegaly: a multicenter study
Accurate prediction of postoperative remission is beneficial for effective patient-physician communication in acromegalic patients. This study aims to train and validate machine learning prediction models for ...
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Article
Surgical outcomes and predictors of glucose metabolism alterations for growth hormone-secreting pituitary adenomas: a hospital-based study of 151 cases
The surgical outcome on glucose metabolism in acromegaly patients is not fully understood. We aimed to investigate the impact of surgery on glucose metabolism and identify key factors that influence alteration...
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Article
Open AccessIdentification of recurrent USP48 and BRAF mutations in Cushing’s disease
Cushing’s disease results from corticotroph adenomas of the pituitary that hypersecrete adrenocorticotropin (ACTH), leading to excess glucocorticoid and hypercortisolism. Mutations of the deubiquitinase gene USP8
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Article
Open AccessClinical features of patients with pituitary stalk thickening: a review of 159 cases from one medical center
Pituitary stalk thickening (PST) used as an imaging diagnosis plays a major role in diagnosis and treatment of the hypothalamus and pituitary disease at an early stage. Up until now, several lines of systemati...
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Article
Open AccessC-peptide is independent associated with diabetic peripheral neuropathy: a community-based study
Because the relationship between C-peptide and diabetic peripheral neuropathy (DPN) is controversial, the aim of our study was to evaluate the relationship between C-peptide and DPN in community-based Chinese ...
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Article
Predictive value of T2 relative signal intensity for response to somatostatin analogs in newly diagnosed acromegaly
The difficulty of predicting the efficacy of somatostatin analogs (SSA) is not fully resolved. Here, we quantitatively evaluated the predictive value of relative signal intensity (rSI) on T1- and T2-weighted m...
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Article
Chronic intermittent hypoxia leads to insulin resistance and impaired glucose tolerance through dysregulation of adipokines in non-obese rats
The aim of this study was to determine whether chronic intermittent hypoxia (CIH) could affect the secretion of adipokines, such as resistin, leptin, and adiponectin, in non-obese rats and to investigate the p...
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Article
Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma
Yao Zhao, Yongyong Shi and colleagues performed a genome-wide association study on sporadic pituitary adenoma in the Han Chinese population. They identify three new susceptibility loci.
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Article
The value of prolactin in inferior petrosal sinus sampling with desmopressin stimulation in Cushing’s disease
Prolactin may reduce false-negative results in diagnosing Cushing’s disease (CD) during inferior petrosal sinus sampling (IPSS). Prolactin normalization could improve the accuracy of IPSS in predicting adenoma...
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Article
Erratum to: Differences in the metabolic status of healthy adults with and without active brown adipose tissue
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Article
Differences in the metabolic status of healthy adults with and without active brown adipose tissue
Previous studies have proven the existence of active brown adipose tissue (BAT) in adults; however, its effect on systematic metabolism remains unclear.
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Article
Therapy with Astragalus polysaccharides rescues lipotoxic cardiomyopathy in MHC-PPARα mice
Obesity-related diabetes mellitus leads to lipotoxic cardiomyopathy resulting in a form of cardiac dysfunction. Mice with heart-specific overexpression of peroxisome proliferator-activated receptor (PPAR) α sh...
