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Article
Influence of Ni impurity ions in electrolyte on the performance of vanadium redox flow battery
The impurity ions have negative effects on the thermal stability and electrochemical performance of the electrolyte, limiting the cycling stability of vanadium redox flow battery (VRFB). Since the Ni ions are ...
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Article
Open AccessTherapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors
We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the high-throughput drug screening (HTS) and genomic sequencing methods. We examined 9 patien...
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Article
Open AccessPan-cancer evaluation of regulated cell death to predict overall survival and immune checkpoint inhibitor response
Regulated cell death (RCD) plays a pivotal role in various biological processes, including development, tissue homeostasis, and immune response. However, a comprehensive assessment of RCD status and its associ...
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Article
Open AccessMachine learning-based investigation of regulated cell death for predicting prognosis and immunotherapy response in glioma patients
Glioblastoma is a highly aggressive and malignant type of brain cancer that originates from glial cells in the brain, with a median survival time of 15 months and a 5-year survival rate of less than 5%. Regula...
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Article
Open AccessFrom glioma gloom to immune bloom: unveiling novel immunotherapeutic paradigms-a review
In tumor therapeutics, the transition from conventional cytotoxic drugs to targeted molecular therapies, such as those targeting receptor tyrosine kinases, has been pivotal. Despite this progress, the clinical...
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Article
Open AccessIdentification of the genetic characteristics of copy number variations in experimental specific pathogen-free ducks using whole-genome resequencing
Specific pathogen-free ducks are a valuable laboratory resource for waterfowl disease research and poultry vaccine development. High throughput sequencing allows the systematic identification of structural var...
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Article
Macroevolution of avian T cell receptor C segments using genomic data
All jawed vertebrates have four T cell receptor (TCR) chains expressed by thymus-derived lymphocytes that play a significant role in animal immune defense. However, avian TCR studies have been limited to a few...
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Article
Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is a prevalent cause of blindness worldwide, resulting in degeneration of retinal ganglion cells and permanent damage to the optic nerve. However, the underlying pathogenetic...
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Article
Structural plasticity of the contralesional hippocampus and its subfields in patients with glioma
To characterize the structural plasticity of the contralesional hippocampus and its subfields in patients with unilateral glioma.
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Article
Open AccessFused expression of Sm1-Chit42 proteins for synergistic mycoparasitic response of Trichoderma afroharzianum on Botrytis cinerea
Sm1 and Chit42 of Trichoderma have been universally confirmed as crucial biocontrol factors against pathogen infection through induced resistance and mycoparasitism, respectively. However, not enough work has bee...
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Article
Open AccessOrganic/inorganic phosphorus partition and transformation in long-term paddy cultivation in the Pearl River Delta, China
Identification and quantification of different soil phosphorus (P) fractions level are important for improving agricultural productivity and develo** sustainable management practices in these agricultural so...
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Article
Open AccessAspartoacylase promotes the process of tumour development and is associated with immune infiltrates in gastric cancer
Aspartoacylase (ASPA) is a gene that plays an important role in the metabolic reprogramming of cancer. However, the clinical relevance of ASPA in gastric cancer (GC) has not been demonstrated.
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Article
Open AccessAssociation between diet and the gut microbiome of young captive red-crowned cranes (Grus japonensis)
Exploring the association of diet and indoor and outdoor environments on the gut microbiome of red-crowned cranes. We investigated the microbiome profile of the 24 fecal samples collected from nine cranes from...
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Article
Open AccessThe irreplaceable role of medical massive open online courses in China during the COVID-19 pandemic
Massive open online courses (MOOCs) have become innovative open-learning approach in medical education. This study aimed to evaluate the dynamic changes in the construction and application of medical MOOCs bef...
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Article
Open AccessCorrection to: Single-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 expression
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Open AccessSingle-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 expression
Glioma is the most common primary central nervous system tumor in adults. Aquaporin-4, as a water channel protein encoded by AQP4 in the brain, is reported to alter its aggregation status to affect plasma memb...
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Article
Research on the Design of Phononic Crystal Rod Band Gaps Based on Lumped Mass Method
Phononic crystals are a kind of artificial functional composite materials with vibration band gaps, which has a wide range of applications in vibration and noise reduction as well as in mechanics. Phononic cry...
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Article
Complete mitochondrial genomes of Lycosa grahami and Lycosa sp. (Araneae: Lycosidae): comparison within the family Lycosidae
Mitochondrial genome (mitogenome) sequencing is one of the most effective methods for studying spider phylogeny. In this study, the mitogenomes of wolf spiders (Lycosa grahami and Lycosa sp.) were sequenced and c...
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Article
Efficacy of first-line systemic treatment regimens for recurrent/metastatic head and neck squamous cell carcinoma: a network meta-analysis
To evaluate the efficacy on overall survival (OS) and progression-free survival (PFS) of the first-line systemic therapy regimens on 6-, 12-, 18-, 24-, and 30 months in recurrent/metastatic head and neck squam...
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Article
Open AccessDesign, methodology, and preliminary results of the non-human primates eye study
To describe the normative profile of ophthalmic parameters in a healthy cynomolgus monkey colony, and to identify the characteristic of the spontaneous ocular disease non-human primates (NHP) models.
