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Article
Open AccessSurgical outcomes and risk factors for surgical complications after en bloc resection following reconstruction with 3D-printed artificial vertebral body for thoracolumbar tumors
The outcomes of patients with tumors of the thoracolumbar spine treated with en bloc resection (EBR) using three-dimensional (3D)-printed endoprostheses are underreported.
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Article
Open AccessCorrection: NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death
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Article
Open AccessNIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death
Photothermal therapy has shown great promise for cancer treatment and second near-infrared (NIR-II) -absorbing particles could further improve its precision and applicability due to its superior penetration de...
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Article
Open AccessIdentification of the miRNA-mRNA regulatory network associated with radiosensitivity in esophageal cancer based on integrative analysis of the TCGA and GEO data
The current study set out to identify the miRNA-mRNA regulatory networks that influence the radiosensitivity in esophageal cancer based on the The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GE...
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Article
Regulating Synthesis of TiO2/CQDS Composite Photocatalysts and Photodegradation of DMSO in Aqueous Suspension
A simple sol–gel method combined with hydrothermal synthesis technique were used to synthesize the rutile TiO2 nanoparticles without any other impurities and TiO2/carbon quantum dots (CQDS) composite photocatalys...
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Article
Open AccessOrganic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy
X-ray-induced photodynamic therapy utilizes penetrating X-rays to activate reactive oxygen species in deep tissues for cancer treatment, which combines the advantages of photodynamic therapy and radiotherapy. ...
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Article
Open AccessComposition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy
Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. Howeve...
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Article
Open AccessIntracellular marriage of bicarbonate and Mn ions as “immune ion reactors” to regulate redox homeostasis and enhanced antitumor immune responses
Different from Fe ions in Fenton reaction, Mn ions can function both as catalyst for chemodynamic therapy and immune adjuvant for antitumor immune responses. In Mn-mediated Fenton-like reaction, bicarbonate ( ...
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Article
Open AccessCarbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors
Paramagnetic complexes containing gadolinium ions have been widely used for magnetic resonance imaging (MRI) in clinic. However, these paramagnetic complexes pose some safety concerns. There is still a demand ...
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Article
Open AccessMinimally invasive separation surgery for the treatment of spinal metastases with small incision and freehand pedicle screw fixation: the surgical learning curve
Minimally invasive separation surgery (MISS) is a safe and effective surgical technique, the current optimal treatment for spinal metastases. However, the learning curve for this technique has not been analyze...
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Article
Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids
Approximately 11% of monogenic diseases involve nonsense mutations that are caused by premature termination codons. These codons can in principle be read-through via the site-specific incorporation of unnatura...
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Article
Open AccessNIR-II emissive AIEgen photosensitizers enable ultrasensitive imaging-guided surgery and phototherapy to fully inhibit orthotopic hepatic tumors
Accurate diagnosis and effective treatment of primary liver tumors are of great significance, and optical imaging has been widely employed in clinical imaging-guided surgery for liver tumors. The second near-i...
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Article
Open AccessX-ray-charged bright persistent luminescence in NaYF4:Ln3+@NaYF4 nanoparticles for multidimensional optical information storage
NaYF4:Ln3+, due to its outstanding upconversion characteristics, has become one of the most important luminescent nanomaterials in biological imaging, optical information storage, and anticounterfeiting applicati...
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Article
Open AccessHybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
Effectively activating macrophages against cancer is promising but challenging. In particular, cancer cells express CD47, a ‘don’t eat me’ signal that interacts with signal regulatory protein alpha (SIRPα) on ...
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Article
LiF@SiO2 nanocapsules for controlled lithium release and osteoarthritis treatment
Electrolytes can be taken orally or intravenously as supplements or therapeutics. However, their therapeutic window may exceed the serum toxicity threshold, making systemic delivery a poor option. Local inject...
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Article
Rethinking cancer nanotheranostics
Advances in nanoparticle synthesis and engineering have produced nanoscale agents affording both therapeutic and diagnostic functions that are often referred to by the portmanteau ‘nanotheranostics’. The field...
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Sustainable Consumption and Production in China
The rising problem of severe resource scarcity, environmental pollution and ecological degradation has become a great constraint on economic development in China. Sustainable consumption and production (SCP), as ...
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Article
High precision landing site map** and rover localization for Chang’e-3 mission
This paper presents the comprehensive results of landing site topographic map** and rover localization in Chang’e-3 mission. High-precision topographic products of the landing site with extremely high resolu...
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Article
The role of tumour-associated MUC1 in epithelial ovarian cancer metastasis and progression
The most common ovarian cancer is epithelial ovarian cancer (EOC) characterised by few early symptoms, widespread peritoneal dissemination and ascites at advanced stages that result in poor prognosis. Despite ...
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Article
Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression
Cancer metastasis and anti-cancer drug resistance are the major reason for the failure of clinical cancer treatment. We evaluated CD147, monocarboxylate transporters (MCT1 and MCT4), and multidrug resistance (...