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Article
Open AccessA novel PH1/pE27HGFK1 nanoparticles for orthotopic glioblastoma therapy
The therapeutic resistance to ionizing radiation (IR) and angiogenesis inhibitors is a great challenge for clinicians in the treatment of glioblastoma, which is associated with Hepatocyte growth factor (HGF)/M...
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Article
CEDG-GeoQA: Knowledge base question answering for the geoscience domain via Chinese entity description graph
Acquiring geoscience knowledge is crucial for advancing earth science research. Currently, geoscience knowledge can be obtained through search engines or specialized databases. However, the quality of search e...
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Article
FBXO11 variants are associated with intellectual disability and variable clinical manifestation in Chinese affected individuals
F-box protein 11 (FBXO11) is a member of F-Box protein family, which has recently been proved to be associated with intellectual developmental disorder with dysmorphic facies and behavioral abnormalities (IDDFBA,...
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Article
Open AccessIntergenerational Ambivalence, Self-differentiation and Ethnic Identity: A Mixed-methods Study on Family Ethnic Socialization
Ethnic identity, profoundly influenced by familial factors, embodies multifaceted layers; yet, the intricate process of family ethnic socialization warrants deeper exploration. This study focuses on exploring ...
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Article
Open AccessSingle-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary neuroendocrine tumors
Pituitary neuroendocrine tumors (PitNETs) are common gland neoplasms demonstrating distinctive transcription factors. Although the role of immune cells in PitNETs has been widely recognized, the precise immuno...
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Article
Open AccessTherapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors
We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the high-throughput drug screening (HTS) and genomic sequencing methods. We examined 9 patien...
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Article
Application of machine learning in prediction of Pb2+ adsorption of biochar prepared by tube furnace and fluidized bed
Data mining by machine learning (ML) has recently come into application in heavy metals purification from wastewater, especially in exploring lead removal by biochar that prepared using tube furnace (TF-C) and...
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Article
Open AccessFully endoscopic far-lateral supracerebellar infratentorial approach for trigeminal neuralgia: illustrative case reports
Trigeminal neuralgia (TN) is a common cause of craniofacial pain. The retrosigmoid approach is usually used to treat TN, but no cases of endoscopic far-lateral supracerebellar infratentorial approach (EF-SCITA...
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Chapter and Conference Paper
Application of BP Neural Network in Pyrolysis Treatment of Organic Solid Waste
The improper management of organic solid waste can precipitate many environmental issues. Pyrolysis, characterized by its capacity for rapid reduction and resource utilization of organic solid waste, has garne...
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Chapter and Conference Paper
Neural-Symbolic Reasoning with External Knowledge for Machine Reading Comprehension
Machine reading comprehension is a fundamental in natural language understanding. Existing large-scale pre-trained language models and graph neural network-based models have achieved good gains on logical reas...
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Chapter and Conference Paper
Evaluation and Perspective of the Thermal Treatment Technologies of Medical Waste for Energy and Value-Added Products
Medical Waste management poses a considerable challenge due to its hazardous nature and environmental concerns associated with its disposal in the healthcare industry. Thermal treatment technologies are sustai...
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Article
Open AccessChromosome microarray analysis combined with karyotype analysis is a powerful tool for the detection in pregnant women with high-risk indicators
Karyotype analysis and fluorescence in situ hybridization (FISH) are commonly used for prenatal diagnosis, however they have many disadvantages. Chromosome microarray analysis (CMA) has the potential to overco...
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Article
Open AccessB7H3 targeting gold nanocage pH-sensitive conjugates for precise and synergistic chemo-photothermal therapy against NSCLC
The combination of drug delivery with immune checkpoint targeting has been extensively studied in cancer therapy. However, the clinical benefit for patients from this strategy is still limited. B7 homolog 3 pr...
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Article
Synthesis of porous carbon from orange peel waste for effective volatile organic compounds adsorption: role of typical components
Volatile organic compounds have posed a serious threat to the environment and human health, which require urgent and effective removal. In recent years, the preparation of porous carbon from biomass waste for ...
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Article
Roles of electrolyte additive in Zn chemistry
Electrolyte regulation plays its critical role in addressing the reversibility issue of metallic Zn anode towards high-performance aqueous zinc ion batteries. In view of the flourish electrolyte additive appro...
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Article
DRD2 expression based on 18F-fallypride PET/MR predicts the dopamine agonist resistance of prolactinomas: a pilot study
The dopamine agonists (DA) have been used widely to treat prolactinomas. However, it is difficult to predict whether the patient will be responsive to DA treatment.
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Article
Open AccessCorrection: Novel fusion protein PK5-RL-Gal-3 C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity
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Article
Open AccessCorrection: Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinoma
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Article
Open AccessNasal microbiota profiles in shelter dogs with dermatological conditions carrying methicillin-resistant and methicillin-sensitive Staphylococcus species
Dermatological conditions may be complicated by Staphylococcus spp. infections influencing skin and nasal microbiota. We investigated the associations between the resident nasal microbiota of shelter dogs with an...
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Article
Open AccessSmall molecule metabolites: discovery of biomarkers and therapeutic targets
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity t...
