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Article
Long-Term Survival and Recurrence Patterns in Locally Advanced Esophageal Squamous Cell Carcinoma Patients with Pathologic Complete Response After Neoadjuvant Chemotherapy Followed by Surgery
The higher pathologic complete response (pCR) after neoadjuvant chemoradiotherapy compared with neoadjuvant chemotherapy for locally advanced esophageal squamous cell carcinoma (ESCC) has not translated into s...
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Article
Long-short interest network with graph-based method for sequential recommendation
In recommender systems, sequence information is crucial. Sequence data contains user preferences and reflects the evolution of user interests over time. Therefore, how to utilize sequence information to captur...
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Article
Association of birthweight and risk of incident dementia: a prospective cohort study
Given the epidemiological studies investigating the relationship between birthweight and dementia are limited. Our study aimed to explore the association between birthweight and the risk of dementia, cognitive...
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Article
Open AccessBNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC
An increasing evidence supports that cell competition, a vital selection and quality control mechanism in multicellular organisms, is involved in tumorigenesis and development; however, the mechanistic contrib...
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Article
Unveiling the therapeutic prospects of IFNW1 and IFNA21: insights into glioma pathogenesis and clinical significance
Glioma, a type of brain tumor, poses significant challenges due to its heterogeneous nature and limited treatment options. Interferon-related genes (IRGs) have emerged as potential players in glioma pathogenes...
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Article
Open AccessWarfarin-related nephropathy: unveiling the hidden dangers of anticoagulation
Warfarin-related nephropathy (WRN) is defined as acute kidney injury subsequent to excessive anticoagulation with warfarin. Patients with mechanical prosthetic valves require long-term anticoagulant therapy. N...
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Article
Open AccessReinforced robotic bean optimization algorithm for cooperative target search of unmanned aerial vehicle swarm
Increasing attention has been given to the utilization of swarm intelligent optimization algorithms to facilitate cooperative target search of unmanned aerial vehicle swarm (UAVs). However, there exist common ...
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Article
Simultaneous Enhancement of Mechanical, Rheological, Heat Resistance, and Thermal/Electrical Properties of Poly(L-lactide)/Poly(D-lactide)/Carbon Fibers Composites
In this work, poly(L-lactide) (PLLA)/poly(D-lactide) (PDLA)/carbon fiber (CF) composites with different PDLA content were prepared by simple melt blending. The stereocomplex (SC) crystallites were in situ form...
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Article
Open AccessMycobacterium tuberculosis produces d-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Adaptation to hypoxia is a major challenge for the survival of Mycobacterium tuberculosis (Mtb) in vivo. Interferon (IFN)-γ-producing CD8+ T cells contribute to control of Mtb infection, in part by promoting anti...
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Article
Open AccessConstructing a screening model to obtain the functional herbs for the treatment of active ulcerative colitis based on herb-compound-target network and immuno-infiltration analysis
The therapeutic effect of most traditional Chinese medicines (TCM) on ulcerative colitis is unclear, The objective of this study was to develop a core herbal screening model aimed at facilitating the transitio...
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Article
Dry season residual straw reduces nitrous oxide emissions during rice season in upland-paddy rotation systems by inhibiting soil denitrification
The mechanism by which residual straw incorporation affects nitrous oxide (N2O) and carbon dioxide equivalent (CO2-eq) emissions throughout the rice season under upland-paddy rotation systems is currently unknown...
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Article
Open AccessThe application of evolutionary computation in generative adversarial networks (GANs): a systematic literature survey
As a subfield of deep learning (DL), generative adversarial networks (GANs) have produced impressive generative results by applying deep generative models to create synthetic data and by performing an adversar...
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Article
Open AccessCDK4/6 inhibitors dephosphorylate RNF26 to stabilize TSC1 and increase the sensitivity of ccRCC to mTOR inhibitors
The combined use of CDK4/6 inhibitors and mTOR inhibitors has achieved some clinical success in ccRCC. Exploring the underlying mechanism of the CDK4/6 pathway in cancer cells and the drug interactions of CDK4...
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Article
Evaluation method of rock brittleness based on post-peak energy conversion under monotonic and cyclic triaxial compression
Rock brittleness and brittle failure play significant roles in deep underground space stability, unconventional gas extraction drilling, hydraulic fracturing efficiency, and coal mining disaster prevention, an...
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Article
Open AccessCapsule Network Based on Double-layer Attention Mechanism and Multi-scale Feature Extraction for Remaining Life Prediction
The era of big data provides a platform for high-precision RUL prediction, but the existing RUL prediction methods, which effectively extract key degradation information, remain a challenge. Existing methods i...
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Article
Nicotine Treatment Ameliorates Blood-Brain Barrier Damage After Acute Ischemic Stroke by Regulating Endothelial Scaffolding Protein Pdlim5
Analysis of a National Institutes of Health (NIH) trial shows that cigarette smoking protected tissue plasminogen activator (tPA)-treated patients from hemorrhage transformation (HT); however, the underlying m...
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Article
Fixed-time control of distributed secondary voltage and frequency for microgrids considering state-constrained
The fixed time control problem for the secondary voltage and frequency of islanded AC microgrids is studied. Based on the multi-agent consensus method, an adaptive fuzzy fixed-time secondary voltage controller...
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Article
Menstrual Blood–Derived Endometrial Stem Cell Transplantation Improves Male Reproductive Dysfunction in T1D Mice by Enhancing Antioxidative Capacity
Diabetes is known to negatively affect male reproduction. Recent clinical results have confirmed that mesenchymal stem cell (MSC)–based therapies are safe and effective for the treatment of diabetes. However, ...
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Article
Open AccessA simplified herbal decoction attenuates myocardial infarction by regulating macrophage metabolic reprogramming and phenotypic differentiation via modulation of the HIF-1α/PDK1 axis
Myocardial infarction (MI) poses a global public health challenge, often associated with elevated mortality rates and a grim prognosis. A crucial aspect of the inflammatory injury and healing process post-MI i...
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Article
Development of a continuum manipulator with variable bending length and piecewise stiffness for transoral laryngeal surgery
Continuum manipulators (CMs) show great potential in transoral laryngeal surgery due to their flexibility. However, CMs for transoral surgery face several issues: large size, which reduces practicality; inters...
