-
Article
Open AccessSalvia miltiorrhiza bunge extracts: a promising source for anti-atopic dermatitis activity
Atopic dermatitis (AD) is a chronic inflammatory condition characterized by the accumulation of reactive oxygen species and the expression of inflammatory factors. Regarding its anti-atopic activity, numerous ...
-
Article
Open AccessMetabolic modulation of Basil (Ocimum basilicum L.): an insight into growth, metabolomics and antioxidant activity under varying temperature and light conditions
Temperature and light are two critical environmental stimuli that greatly impact our agricultural industry. We explored the effects of varying temperature and light conditions on the metabolomics of basil, a p...
-
Article
Pseudocitrobacter anthropi reduces heavy metal uptake and improves phytohormones and antioxidant system in Glycine max L.
Heavy metal contamination due to anthropogenic activities is a great threat to modern humanity. A novel and natural technique of bioremediation using microbes for detoxification of heavy metals while improving...
-
Article
Open AccessCorrection: Corrigendum: PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs
Scientific Reports 6: Article number: 34617; published online: 06 October 2016; updated: 27 September 2017. This Article contains incorrect versions of Figure 3 and Figure 6. The correct Figures appear below a...
-
Article
Open AccessPTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs
PTEN is a tyrosine phosphatase with significant function in inhibiting STAT3 activation. Recently, inactivation of STAT3 has been demonstrated as a therapeutic candidate for autoimmune arthritis. The expressio...
-
Article
Open AccessErratum to: Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance
-
Article
Open AccessAmelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance
Foxp3 is a key regulator of the development and function of regulatory T cells (Tregs), and its expression is thought to be T cell-restricted. We found that B cells in mice can express Foxp3 and B cells expres...
-
Article
The dynamic evolution of rheumatology in Korea
During the past 35 years rheumatology in Korea has progressed remarkably swiftly in terms of academic activity, clinical practice and health care. However, the future of rheumatology in Korea requires continue...
-
Article
RNA-Seq Analysis of Spatiotemporal Gene Expression Patterns During Fruit Development Revealed Reference Genes for Transcript Normalization in Plums
Transcriptional analysis that uncovers fruit ripening-related gene regulatory networks is increasingly important to maximize quality and minimize losses of economically important fruits such as plums. RNA sequ...
-
Article
Open AccessGreen Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway
The activity of one of the major catechins in Green Tea, the polyphenol (−)-epigallocatechin-3-gallate (EGCG), has been shown to have a variety of health benefits. Recent studies suggest that EGCG can modulate...
-
Article
A pathogenetic role for IL-21 in primary Sjögren syndrome
Kim et al. hypothesize that IL-21 is crucial to the pathogenesis of primary Sjögren syndrome (pSS), focusing on evidence of an interplay between the innate and adaptive immune responses mediated by the effects of...
-
Article
Open AccessGeneration of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis
Since the concept of reprogramming mature somatic cells to generate induced pluripotent stem cells (iPSCs) was demonstrated in 2006, iPSCs have become a potential substitute for embryonic stem cells (ESCs) giv...
-
Article
Treating rheumatoid arthritis to target: recommendations assessment questionnaire in Korea
Treat rheumatoid arthritis (RA) to target (T2T) is an international initiative to provide the rheumatology community with clear direction on treatment targets for RA. We performed a nationwide survey in Korea ...
-
Article
Open AccessIn vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis
Interleukin (IL)-27 is a novel cytokine of the IL-6/IL-12 family that has been reported to be involved in the pathogenesis of autoimmune diseases and has a pivotal role as both a pro- and anti-inflammatory cyt...
-
Article
Shared epitope and radiologic progression are less prominent in elderly onset RA than young onset RA
The aim of this study was to determine the influence of HLA-DRB1 and HLA-DQB1 genes on the disease susceptibility and the disease severity in elderly onset rheumatoid arthritis (EORA) compared with young onset...
-
Article
Tacrolimus treatment increases bone formation in patients with rheumatoid arthritis
Tacrolimus is a calcineurin inhibitor, and it is used for the treatment of rheumatoid arthritis (RA). It works by inhibiting nuclear factor of activated T cells and inducting immunosuppression. This study aims...
-
Article
Follow-up of primary Sjogren’s syndrome patients presenting positive anti-cyclic citrullinated peptides antibody
Anti-cyclic citrullinated peptide antibody (anti-CCP antibody) is very useful for the diagnosis of rheumatoid arthritis (RA) and is associated with articular erosions. The specificity of anti-CCP antibody in t...
-
Article
Macrophage activation syndrome resistant to medical therapy in a patient with systemic lupus erythematosus and its remission with splenectomy
Macrophage activation syndrome (MAS) is a rare, but potentially life-threatening complication of systemic lupus erythematosus (SLE). A bone marrow biopsy often provides pathologic evidence of MAS, and MAS usua...
-
Article
Open AccessIL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation
Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades adjacent cartilage and bone in rheumatoid arthritis (RA). The study was undertaken to determine the effect of interleu...
-
Article
Augmented chondroprotective effect of coadministration of celecoxib and rebamipide in the monosodium iodoacetate rat model of osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease characterized by the progressive loss of articular cartilage and chronic pain. Although cyclooxygenase-2 (COX-2) inhibitors such as celecoxib are recommended...
