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Article
Keys to the Diagnosis of Neonatal Dural Sinus Compression with Intracerebral Hemorrhage: a Case Report
Differential diagnosis between dural sinus compression and cerebral venous thrombosis (CVT) in neonates will ensure adequate treatments and improve patient care. However, differential diagnosis can be difficul...
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Article
Open AccessAnti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice
Previously we established an arthritis-prone FcγRIIB-deficient mouse strain (designated KO1). Anti-mouse CD11b mAb (5C6) has been reported to inhibit the recruitment of peripheral CD11b+ myelomonocytic cells from...
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Article
Open AccessClinical Factors Associated with Initial Decrease in Body-Fat Percentage Induced by Add-on Sodium-Glucose Co-transporter 2 Inhibitors in Patient with Type 2 Diabetes Mellitus
Obesity is globally recognized as an important clinical problem and sodium-glucose co-transporter 2 (SGLT2) inhibitors are considered a suitable therapy for obese patients with type 2 diabetes mellitus (T2DM)....
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Article
Open AccessEffects of Edaravone on Muscle Atrophy and Locomotor Function in Patients with Ischemic Stroke
Background and Objective: Stroke patients with severe leg paralysis are often bedridden in the acute and subacute phase, which increases the risk of disuse muscle atrophy in the chronic phase. Th...
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Article
Mechanisms of γ-hydroxybutyric acid production during the early postmortem period
Although postmortem production of γ-hydroxybutyric acid (GHB) has been confirmed, its production pathways and substrates have not been sufficiently clarified. To confirm that the residual enzymes are involved ...
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Article
Significance of MHC class II haplotypes and IgG Fc receptors in SLE
Systemic lupus erythematosus (SLE) is a systemic antibody-mediated autoimmune disease that develops under the control of multiple susceptibility genes. Genetic studies in murine and human SLE have identified s...
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Article
Four mutations of the spastin gene in Japanese families with spastic paraplegia
Hereditary spastic paraplegia (HSP) is a group of genetically heterogeneous neurodegenerative disorders characterized by slowly progressive spasticity and weakness of the lower limbs. HSP is caused by failure ...
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Chapter
ANTIMICROBIAL AND NEMATICIDAL SUBSTANCES FROM THE ROOT OF CHICORY(Cichorium intybus)
Antimicrobial sesquiterpenoids, 8a-angeloyloxycichoralexin and guaianolides such as cichoralexin and 10a-hydroxycichopumilide were isolated and identified from the root of chicory (Cichorium intybus). These sesqu...
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Article
An Arginine Specific Protease from Spirulina platensis
An arginine specific protease, Sp-protease, was purified by column chromatography from freeze-dried Spirulina platensis using a five-step process. Purified Sp-protease has a molecular weight of 80 kDa. It hydroly...
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Article
Complete Nucleotide Sequence and Phylogenetic Analyses of Hepatitis B Virus Isolated from Two Pileated Gibbons
We analyzed full-length sequence of hepatitis B virus (HBV) recovered from two pileated gibbons (Hylobates pileatus) originally born in East Asia. Two animals possessed a viral genome of 3182 nt in length with a ...
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Article
Genome Screening for Susceptibility Loci in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a complex, multigenic autoimmune disease with a wide spectrum of clinical manifestations. Much of the pathology is attributed to deposition to various tissues of immune co...
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Article
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Programmed death 1 (PD-1)–deficient mice develop a variety of autoimmune-like diseases, which suggests that this immunoinhibitory receptor plays an important role in tolerance. We identify here PD-1 ligand 2 (...
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Article
ORP150 protects against hypoxia/ischemia-induced neuronal death
Oxygen-regulated protein 150 kD (ORP150) is a novel endoplasmic-reticulum–associated chaperone induced by hypoxia/ischemia. Although ORP150 was sparingly upregulated in neurons from human brain undergoing isch...
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Protocol
Polyethylene Glycol-Modified Enzymes in Hydrophobic Media
Chemical modification of proteins with polyethylene glycol (PEG), a nontoxic, nonimmunogenic, and amphipathic polymer, has been extensively studied for the purpose of applying proteins to biomedical and biotec...
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Chapter and Conference Paper
The regulation of PD-1/PD-L1 pathway and autoimmune diseases
PD-1 is an immuno-inhibitory receptor which belongs to the immunoglobulin superfamily and expressed on activated T, B and myeloid cells. Engagement of the PD-1 receptor with its membrane bound ligand (PD-L1) o...
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Article
Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene
Tight skin mice (TSK) bear a mutated Fibrillin-1 (Fbn-1) gene. Genetic studies show that the TSK mutation is closely associated with the Fbn-1 locus (0–0.7 cM). A previous study showed two recombinants between...
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Article
Allelochemicals in Chicory and Utilization in Processed Foods
In connection with a proposed defensive mechanism of chicory, antimicrobial, and nematicidal substances from the rhizomes were studied. A new antimicrobial sesquiterpenoid, 8α-angeloyloxycichoralexin, in addit...
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Article
Isolation of Biopterin-α-glucoside from Spirulina (Arthrospira) platensis and Its Physiologic Function
A fluorescent substance was isolated from the cyanobacterium with a yield of 4.5 mg per 10 g of dried Spirulina (Arthrospira) platensis cells by gentle extraction and ethanol fractionation followed by column chr...
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Article
Regioselective deacetylation of peracetylated monosaccharide derivatives by polyethylene glycol-modified lipase for the oligosaccharide synthesis
Lipase modified with polyethylene glycol became soluble and active in organic solvents, and catalyzed regioselective deacetylation of peracetylated monosaccharide derivatives in 1,1,1-trichloroethane. The deac...
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Article
Anti-inflammatory activity of superoxide dismutase conjugated with sodium hyaluronate
Superoxide dismutase (SOD) from bovine erythrocytes was conjugated with sodium hyaluronate (HA) with a mean molecular weight of 106 to have greater anti-inflammatory activity in vivo. Amino groups of SOD were ...
