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Article
Open AccessMicrowave-multiplexed qubit controller using adiabatic superconductor logic
Cryogenic qubit controllers (QCs) are the key to build large-scale superconducting quantum processors. However, develo** scalable QCs is challenging because the cooling power of a dilution refrigerator is to...
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Article
Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity
As aberrant accumulation of RNA–DNA hybrids (R-loops) causes DNA damage and genome instability, cells express regulators of R-loop structures. Here we report that RNA-dependent RNA polymerase (RdRP) activity o...
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Article
Open AccessMint3-depletion-induced energy stress sensitizes triple-negative breast cancer to chemotherapy via HSF1 inactivation
Given the lack of therapeutic targets, the conventional approach for managing triple-negative breast cancer (TNBC) involves the utilization of cytotoxic chemotherapeutic agents. However, most TNBCs acquire res...
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Article
Open AccessPosttreatment liver function, but not baseline liver function stratifies patient survival after direct-acting antiviral treatment in decompensated cirrhosis with hepatitis C virus
The prognosis of cirrhosis is clearly stratified by liver function. Although direct-acting antiviral (DAA) has recently been used to eliminate hepatitis C virus (HCV), it is not clear whether liver function st...
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Article
A case of frequent hypoglycemic attacks successfully controlled with capecitabine plus temozolomide and 177Lu-DOTATATE peptide receptor radionuclide therapy in a patient with recurrent pancreatic insulinoma
A 59-year-old woman with metastatic pancreatic insulinoma, having undergone several treatment regimens including sunitinib, everolimus, lanreotide and streptozocin plus 5-fluorouracil, was admitted to our hosp...
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Article
Open AccessCase report: therapeutic monitoring of vancomycin in an acute liver failure patient with anuria under high-flow continuous hemodiafiltration
High-flow continuous hemodiafiltration (HF-CHDF) combines diffusive and convective solute removal and is employed for artificial liver adjuvant therapy. However, there is no report on dosage planning of vancom...
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Article
Open AccessEfficacy of a novel self-expandable metal stent with dumbbell-shaped flare ends for distal biliary obstruction due to unresectable pancreatic cancer
This study aimed to evaluate the efficacy of a novel fully covered self-expandable metal stent (SEMS) with dumbbell-shaped flare ends for the palliation of distal biliary obstruction (DBO) due to unresectable ...
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Article
Esophago-aortic fistula of esophageal cancer after chemotherapy, proton therapy and salvage photodynamic therapy: a rescued case
We describe a case of esophageal cancer after proton therapy that resulted in an esophagoaortic fistula after photodynamic therapy (PDT). A 49-year-old woman with esophageal cancer (cT1bN0M0, cStage I) underwe...
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Article
Open AccessLeukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET
Retinoic acid-inducible gene (RIG)-I is an essential innate immune sensor that recognises pathogen RNAs and induces interferon (IFN) production. However, little is known about how host proteins regulate RIG-I ...
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Article
Open AccessPeptide vaccine-treated, long-term surviving cancer patients harbor self-renewing tumor-specific CD8+ T cells
The behaviors and fates of immune cells in cancer patients, such as dysfunction and stem-like states leading to memory formation in T cells, are in intense focus of investigation. Here we show, by post hoc ana...
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Article
Open AccessWeak spin-flip scattering in Pd89Ni11 interlayer of NbN-based ferromagnetic Josephson junctions
We studied niobium nitride (NbN)-based π-junctions with a diluted ferromagnetic Pd89Ni11 interlayer (NbN/PdNi/NbN junctions). In the NbN/PdNi/NbN junctions with various PdNi thicknesses, we observed a non-monoton...
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Article
Liver-related events after direct-acting antiviral therapy in patients with hepatitis C virus-associated cirrhosis
Direct-acting antiviral (DAA) therapy enables a high rate of sustained virologic response (SVR) in patients with hepatitis C virus associated cirrhosis. However, the impact of DAA therapy on liver-related even...
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Article
Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis
Gut dysbiosis is observed in chronic hepatobiliary diseases and is frequently associated with liver carcinogenesis; however, the extent and specific mechanisms triggered by alterations in the microbiota mediat...
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Article
Open AccessEnhanced coherence of all-nitride superconducting qubits epitaxially grown on silicon substrate
Improving the coherence of superconducting qubits is a fundamental step towards the realization of fault-tolerant quantum computation. However, coherence times of quantum circuits made from conventional alumin...
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Article
Open AccessEstablishment of liver tumor cell lines from atherogenic and high fat diet fed hepatitis C virus transgenic mice
A syngeneic mouse model bearing a transplanted tumor is indispensable for the evaluation of the efficacy of immune checkpoint inhibitors (ICIs). However, few syngeneic mouse models of liver cancer are availabl...
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Article
The characteristics of the immune cell profiles in peripheral blood in cholangiocarcinoma patients
Immune related cells are known to be closely related to the therapeutic effects and prognoses of cancer patients. In this study, we analyzed immune cell profiles (ICP) of cholangiocarcinoma patients (CCA).
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Article
Sofosbuvir plus velpatasvir treatment for hepatitis C virus in patients with decompensated cirrhosis: a Japanese real-world multicenter study
Real-world data on the efficacy and safety of sofosbuvir plus velpatasvir (SOF/VEL) treatment for patients with hepatitis C virus (HCV)-related decompensated cirrhosis are limited in Japan.
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Natural Environment and Management for Children’s Play and Learning in Kindergarten in an Urban Forest in Kyoto, Japan
There is a great and growing concern about the connection between children and nature in modern society. Conservation and management of natural areas is very important both for providing nature experiences for...
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Article
Tumor lysis syndrome in a patient with metastatic melanoma treated with nivolumab
A 79-year-old man with metastatic melanoma of the right maxillary sinus and multiple liver metastases received a single dose of nivolumab. Eight days later, he experienced impaired consciousness, accompanied b...
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Article
Open Accessπ phase shifter based on NbN-based ferromagnetic Josephson junction on a silicon substrate
In the field of superconducting electronics, a π phase shifter based on a ferromagnetic Josephson junction is expected to provide various advantages to classical and quantum superconducting devices. Here we re...
