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  1. No Access

    Chapter

    Elucidation and Control of the Mechanisms Underlying Chronic Inflammation Mediated by Invariant Natural Killer T Cells

    Invariant natural killer T (iNKT) cells are a subpopulation of T lymphocytes with unique specificities against (glyco)lipids presented in the context of CD1d belonging to major histocompatibility complex (MHC)...

    Hiroshi Watarai in Chronic Inflammation (2016)

  2. No Access

    Chapter

    Introduction: Mechanisms of NKT-Cell-Mediated Adjuvant Activity and Function of iPS-Derived NKT Cells

    Natural killer T (NKT) cells are characterized by the expression of an invariant Vα14Jα18 receptor that recognizes glycolipids such as α-galactosylceramide (α-GalCer) in conjunction with CD1d molecule. Functio...

    Masaru Taniguchi, Shin-ichiro Fujii, Toshinori Nakayama… in Natural Killer T cells (2012)

  3. No Access

    Article

    The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

    Chronic stimulation of lymphocytes results in upregulation of immunomodulatory IL-10, but the molecular mechanisms of this process have remained unknown. Kubo and colleagues demonstrate that the transcription ...

    Yasutaka Motomura, Hiroshi Kitamura, Atsushi Hijikata, Yuko Matsunaga… in Nature Immunology (2011)

  4. No Access

    Article

    Regulation of IL-9 expression by IL-25 signaling

    How IL-9 expression is regulated remains unclear. Dong and co-workers show that the IL-25–IL-17RB pathway is central to the physiological regulation of this cytokine in vivo.

    Pornpimon Angkasekwinai, Seon Hee Chang, Manoj Thapa, Hiroshi Watarai… in Nature Immunology (2010)