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  1. Article

    Open Access

    The Clinical Efficacy of Fibrinogen Concentrate in Massive Obstetric Haemorrhage with Hypofibrinogenaemia

    Massive obstetric haemorrhage remains a major cause of maternal death attributable to hypofibrinogenaemia. Transfusion of large volumes of fresh frozen plasma (FFP) is required to normalise fibrinogen levels. ...

    Shigetaka Matsunaga, Yasushi Takai, Eishin Nakamura, Sumiko Era… in Scientific Reports (2017)

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  2. No Access

    Article

    Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study

    It has been suggested that micronutrients such as alpha-tocopherol, retinol, lutein, cryptoxanthin, lycopene, and alpha- and beta-carotene may help in the prevention of cervical cancer. Our aim was to investig...

    Takuma Fujii, Naoyoshi Takatsuka… in International Journal of Clinical Oncology (2013)

  3. No Access

    Article

    Subsequent risks for cervical precancer and cancer in women with low-grade squamous intraepithelial lesions unconfirmed by colposcopy-directed biopsy: results from a multicenter, prospective, cohort study

    To investigate the natural course of low-grade squamous intraepithelial lesions (LSILs) that cannot be histologically confirmed by colposcopy-directed biopsy.

    Koji Matsumoto, Yasuo Hirai, Reiko Furuta… in International Journal of Clinical Oncology (2012)

  4. No Access

    Article

    Five-year results of cyclic semi-high dose neoadjuvant chemotherapy supported by autologous peripheral blood stem-cell transplantation in patients with advanced ovarian cancer

    To achieve anti-ovarian tumor responses similar to those obtained with high-dose chemotherapy but with milder side effects, we developed a treatment protocol in which semi-high dose multi-cycle neoadjuvant che...

    Kazunori Ikeba, Mitsuo Okubo, Satoru Takeda… in International Journal of Clinical Oncology (2004)

  5. No Access

    Article

    Two newly identified HLA-DRB1 alleles: DRB1 * 1322 and DRB1 * 1327

    Karen J. Duran, Hiroo Maeda, Henny G. Otten, Rene De Vries… in Immunogenetics (1997)

  6. No Access

    Chapter

    Two-Dimensional IEF Analysis of DR, DQ, and DP Molecules from DRW8-Carrying Haplotypes

    HLA-DR, DQ, and DP molecules were isolated from eight HLA-DRw8 homozygous B-cell lines using the monoclonal antibodies (MAb) submitted to the 10th International Histocompatibility Workshop. These molecules wer...

    Hiroo Maeda, Ranko Hirata, Takeo Juji in Immunobiology of HLA (1989)

  7. No Access

    Chapter

    HLA Antigens in Japanese Patients with Childhood-Onset Myasthenia Gravis

    Myasthenia gravis (MG) is an autoimmune disorder that affects neuromuscular junctions. In Japanese, the age of onset of MG shows a bimodal distribution, with the first and highest peak before the age of two an...

    Kazumasa Matsuki, Jiro Numaga, Masaru Takamizawa, Hiroo Maeda… in Immunobiology of HLA (1989)

  8. No Access

    Chapter

    Three Subtypes of DRw52 Molecules Among DR3, DR5, and DRw6 Haplotypes

    In the HLA-DR subregion, two allelic series of DR molecules, DR1-DRw14 and DRw52–DRw53, have been recognized. DRw52 is supertypic to DR and is found in association with DR3, DR5, DRw6, and DRw8. We recently pr...

    Ranko Hirata, Hiroo Maeda, Hiroshi Tohyama, Tetsuo Ishikawa in Immunobiology of HLA (1989)

  9. No Access

    Chapter and Conference Paper

    DQw4 (Wa): 2-D Gel Patterns

    DQw4 (Wa) is a class II specificity defined in the 10th Workshop as a fourth allele at the DQ locus. It is revealed serologically with the mouse monoclonal antibody Hu-46, which reacts with some DR4 and DRw8 h...

    Lydia Kulova, Hiroo Maeda, Ronald Bontrop, Nigel Rust, Susan Fuggle… in Immunobiology of HLA (1989)

  10. No Access

    Chapter

    DR2 and DQw1 Molecules in Narcolepsy

    Narcolepsy is a clinical disease entity characterized by excessive daytime sleepiness and cataplexy. The cause and genetic basis for the disease has been unknown until 1984, when an extraordinary association b...

    Hiroo Maeda, Ranko Hirata, Kazumasa Matsuki, Takeo Juji… in Immunobiology of HLA (1989)

  11. No Access

    Chapter and Conference Paper

    DRw8: 2-D Gel Patterns

    Five DRw8,Dw8 cell lines (Table 1) that have been previously characterized serologically and cellularly (4,5) were analyzed in this study. The biochemical analysis of their class II antigens was performed usin...

    Lydia Kulova, Ronald Bontrop, Soo Young Yang, Hiroo Maeda in Immunobiology of HLA (1989)

  12. No Access

    Article

    Taq I-generated HLA-DQ αpolymorphism in Japanese patients with narcolepsy

    Taq I-generated HLA-DQαrestriction fragment length polymorphism was examined in Japanese patients with narcolepsy. All patients were DR2 positive and shared a 6.0 kb fragment, although this fragment was found onl...

    Kazumasa Matsuki M.D., Hiroo Maeda, Takeo Juji, Hidetoshi Inoko… in Immunogenetics (1988)

  13. No Access

    Article

    Defective expression of HLA class I antigens: A case of the bare lymphocyte without immunodeficiency

    A case of the bare lymphocyte without apparent immunodeficiency was observed in a 33-year-old woman who had no history of severe infections but suffered from sino-bronchial disease. No HLA-A and -B antigens (c...

    Hiroo Maeda, Ranko Hirata, Rou-Fuie Chen, Harumi Suzaki, Shoji Kudoh… in Immunogenetics (1985)

  14. No Access

    Article

    Identification of the MT3 molecule using two-dimensional gel electrophoresis and alloantisera

    The MT3 antigen is defined serologically as a DR supertypic specificity and is strongly associated with DR4, DR7, and DRw9. To determine whether the MT3 molecule is distinct from the DR molecule, DR4 and MT3 a...

    Manabu Suzuki, Hiroo Maeda, Ryozaburo Mukai, Toshio Yabe, Hideo Hamaguchi in Immunogenetics (1983)