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  1. Article

    Open Access

    Prevention of postoperative intrapericardial adhesion by dextrin hydrogel

    Postoperative intrapericardial adhesion increases the risk of complications in patients undergoing reoperation. We investigated the effect of a bioabsorbable dextrin hydrogel (DHG) on the formation of intraper...

    Satoshi Kikusaki, Kazuyoshi Takagi in General Thoracic and Cardiovascular Surgery (2021)

  2. Article

    Open Access

    Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model

    Aortic dissection is a life-threatening condition, which is characterised by separation of the constituent layers of the aortic wall. We have recently shown that monocyte/macrophage infiltration into the aorti...

    Shota Tomida, Kenichi Aizawa, Norifumi Nishida, Hiroki Aoki in Scientific Reports (2019)

  3. Article

    Open Access

    Propagation-based phase-contrast synchrotron imaging of aortic dissection in mice: from individual elastic lamella to 3D analysis

    In order to show the advantage and potential of propagation-based phase-contrast synchrotron imaging in vascular pathology research, we analyzed aortic medial ruptures in BAPN/AngII-infused mice, a mouse model...

    Gerlinde Logghe, Bram Trachet, Lydia Aslanidou in Scientific Reports (2018)

  4. No Access

    Chapter

    Mouse Model of Abdominal Aortic Aneurysm Induced by CaCl2

    Abdominal aortic aneurysm (AAA) is a common and fatal disease for which pathogenesis is still uncertain. Reproducible and standardized animal model of AAA is essential to obtain the knowledge of the molecular ...

    Hiroki Aoki, Satoko Ohno, Aya Furusho in Mouse Models of Vascular Diseases (2016)

  5. Chapter

    Tissue Remodeling in Vascular Wall in Kawasaki Disease-Related Vasculitis Model Mice

    Kawasaki disease is the most common acute systemic vasculitis of unknown etiology in children [1] and can cause inflammation of the coronary arteries leading to aneurysms. Tenascin-C, an extracellular matrix p...

    Yukako Yoshikane, Mitsuhisa Koga, Tamaki Cho in Etiology and Morphogenesis of Congenital H… (2016)

  6. No Access

    Article

    Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma

    Aortic dissection and intramural haematoma comprise an aortopathy involving separation of the aortic wall. Underlying mechanisms of the condition remain unclear. Here we show that granulocyte macrophage colony...

    Bo-Kyung Son, Daigo Sawaki, Shota Tomida, Daishi Fujita in Nature Communications (2015)

  7. Article

    Open Access

    Tenascin C protects aorta from acute dissection in mice

    Acute aortic dissection (AAD) is caused by the disruption of intimomedial layer of the aortic walls, which is immediately life-threatening. Although recent studies indicate the importance of proinflammatory re...

    Taizo Kimura, Kozoh Shiraishi, Aya Furusho, Sohei Ito, Saki Hirakata in Scientific Reports (2014)

  8. No Access

    Chapter and Conference Paper

    On Formal Series of Jacobi Forms and Borcherds Products

    By Fourier-Jacobi expansion, a Siegel modular form of degree 2 gives a family of Jacobi forms of weight k and index ...

    Hiroki Aoki in Automorphic Forms (2014)

  9. Article

    Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice

    Lysyl oxidase (LOX) and LOX-like protein-1 (LOXL-1) are extracellular matrix-embedded amine oxidases that have critical roles in the cross-linking of collagen and elastin. LOX family proteins are abundantly ex...

    Haruya Ohmura, Hideo Yasukawa, Tomoko Minami, Yusuke Sugi in Hypertension Research (2012)

  10. Article

    Open Access

    Sex and age-level differences of walking time in preschool children on an obstacle frame

    Step** over an obstacle is a kind of compound movement that makes walking more difficult, especially for preschool children. This study examines sex and age-level differences in walking time in preschool chi...

    Kosho Kasuga, Shin-ichi Demura, Hiroki Aoki in Journal of Physiological Anthropology (2012)

  11. No Access

    Chapter and Conference Paper

    Regression of Abdominal Aortic Aneurysms through Pharmacologic Therapy

    Abdominal aortic aneurysm (AAA) is a common disease that eventually results in aortic rupture with high mortality. Although a pharmacologic therapy for AAA is eagerly awaited, the destruction of the aortic wal...

    Koichi Yoshimura, Hiroki Aoki, Yasuhiro Ikeda in Advances in Understanding Aortic Diseases (2009)

  12. No Access

    Article

    Turning back the clock: regression of abdominal aortic aneurysms via pharmacotherapy

    Abdominal aortic aneurysm (AAA) is a common disease that causes progressive expansion and rupture of the aorta with high mortality. There is a large and unmet need for nonsurgical treatment for AAA. Research h...

    Hiroki Aoki, Koichi Yoshimura, Masunori Matsuzaki in Journal of Molecular Medicine (2007)

  13. No Access

    Article

    Generalizations of Ho–Lee’s binomial interest rate model I: from one- to multi-factor

    In this paper a multi-factor generalization of Ho–Lee model is proposed. In sharp contrast to the classical Ho–Lee, this generalization allows for those movements other than parallel shifts, while it still is ...

    Jirô Akahori, Hiroki Aoki, Yoshihiko Nagata in Asia-Pacific Financial Markets (2006)

  14. No Access

    Article

    Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase

    Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when surgical treatment is inapplicable, results in progressive expansion and rupture of the aorta with high mortality. Although n...

    Koichi Yoshimura, Hiroki Aoki, Yasuhiro Ikeda, Kozo Fujii, Norio Akiyama in Nature Medicine (2005)

  15. No Access

    Protocol

    Gene Silencing Using Adenoviral RNAi Vector in Vascular Smooth Muscule Cells and Cardiomyocytes

    RNA interference (RNAi) is a new and rapidly progressing technology for facilitating functional gene silencing. To perform highly efficient RNAi in cardiomyocytes, vascular smooth muscle cells, and vascular en...

    Hideko Kasahara, Hiroki Aoki in Molecular Cardiology (2005)

  16. No Access

    Article

    The graded ring of hermitian modular forms of degree 2

    Hiroki Aoki in Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg (2002)

  17. No Access

    Article

    Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro

    During the development of hypertrophy, cardiac myocytes increase organization of the sarcomere, a highly ordered contractile unit in striated muscle cells. Several hypertrophic agonists, such as angiotensin II...

    Hiroki Aoki, Junichi Sadoshima, Seigo Izumo in Nature Medicine (2000)

  18. No Access

    Article

    Calcineurin—the missing link in cardiac hypertrophy

    Transgenic mice that overexpress calcineurin develop cardiac hypertrophy, which can be prevented by treatment with immunosuppressive drugs that inhibit calcineurin.

    Seigo Izumo, Hiroki Aoki in Nature Medicine (1998)