Abstract
Abdominal aortic aneurysm (AAA) is a common and fatal disease for which pathogenesis is still uncertain. Reproducible and standardized animal model of AAA is essential to obtain the knowledge of the molecular pathogenesis for develo** novel diagnostic and therapeutic strategies. In this regard, CaCl2-induced mouse model of AAA (Ca model) has several advantages. The histopathology of Ca model recapitulates important features of human AAA, including chronic inflammation, progressive destruction of elastic lamellae with preserved triple layers of aortic wall, and expansion of aortic diameter. The procedure has been well established and widely used to decipher the roles of key molecules in AAA. Because Ca model is induced by a simple chemical stimulus, the result is highly reproducible qualitatively and quantitatively once the surgical technique is established. In this section, we describe the step-by-step procedure for creating Ca model of AAA in mice. The standard methods for the evaluation and analysis of the aortic aneurysm are also provided.
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Aoki, H. et al. (2016). Mouse Model of Abdominal Aortic Aneurysm Induced by CaCl2 . In: Sata, M. (eds) Mouse Models of Vascular Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55813-2_10
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DOI: https://doi.org/10.1007/978-4-431-55813-2_10
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