8 Result(s)
within
Hirokazu Kimura
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessGalectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins
Autophagy has been linked to a wide range of functions, including a degradative process that defends host cells against pathogens. Although the involvement of autophagy in HBV infection has become apparent, it...
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Article
Open AccessPIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed ...
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Article
Open AccessThe tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein
Diverse cellular proteins and RNAs are tightly regulated in their subcellular localization to exert their local function. Here we report that the tumour suppressor adenomatous polyposis coli protein (APC) dire...
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Article
Open AccessMolecular evolution of the capsid gene in human norovirus genogroup II
Capsid protein of norovirus genogroup II (GII) plays crucial roles in host infection. Although studies on capsid gene evolution have been conducted for a few genotypes of norovirus, the molecular evolution of ...
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Article
Open AccessMolecular Evolution of the Capsid Gene in Norovirus Genogroup I
We studied the molecular evolution of the capsid gene in all genotypes (genotypes 1–9) of human norovirus (NoV) genogroup I. The evolutionary time scale and rate were estimated by the Bayesian Markov chain Mon...
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Article
Open AccessMolecular evolution of haemagglutinin (H) gene in measles virus
We studied the molecular evolution of the haemagglutinin (H) gene (full length) in all genotypes (24 genotypes, 297 strains) of measles virus (MeV). The gene’s evolutionary timescale was estimated by the Bayesian...
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Article
Open AccessASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction
APOBEC3G (A3G) is an innate antiviral restriction factor that strongly inhibits the replication of human immunodeficiency virus type 1 (HIV-1). An HIV-1 accessory protein, Vif, hijacks the host ubiquitin–prote...
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Article
Open AccessMolecular evolution of the VP1, VP2 and VP3 genes in human rhinovirus species C
Human rhinovirus species C (HRV-C) was recently discovered and this virus has been associated with various acute respiratory illnesses (ARI). However, the molecular evolution of the major antigens of this viru...
