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  1. Article

    Open Access

    Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins

    Autophagy has been linked to a wide range of functions, including a degradative process that defends host cells against pathogens. Although the involvement of autophagy in HBV infection has become apparent, it...

    Kei Miyakawa, Mayuko Nishi, Michinaga Ogawa, Satoko Matsunaga… in Nature Communications (2022)

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  2. Article

    Open Access

    PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

    Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed ...

    Kei Miyakawa, Satoko Matsunaga, Masaru Yokoyama, Masako Nomaguchi… in Nature Communications (2019)

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    Article

    Lnc RNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness

    Aldehyde dehydrogenase1 (ALDH1) is widely accepted as a stem cell marker for normal breast as well as in breast cancer. Although the clinical impact of ALDH1 was observed in our previous study, we do not know ...

    Hidetaka Shima, Kumiko Kida, Shoko Adachi… in Breast Cancer Research and Treatment (2018)

  4. Article

    Open Access

    The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein

    Diverse cellular proteins and RNAs are tightly regulated in their subcellular localization to exert their local function. Here we report that the tumour suppressor adenomatous polyposis coli protein (APC) dire...

    Kei Miyakawa, Mayuko Nishi, Satoko Matsunaga, Akiko Okayama… in Nature Communications (2017)

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