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Article
Open AccessEffects of obesity on CC16 and their potential role in overweight/obese asthma
Club cell secretory protein-16 (CC16) is a major anti-inflammatory protein expressed in the airway; however, the potential role of CC16 on overweight/obese asthma has not been assessed. In this study, we exami...
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Article
Whole genome sequencing and evolutionary analysis of G8P [8] rotaviruses emerging in Japan
Unusual DS-1-like intergenogroup reassortant rotaviruses with a bovine-like G8 genotype (DS-1-like G8P [8] rotaviruses) have emerged and rapidly spread in several countries. In this study, the nucleotide seque...
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Article
Lymphocytic panhypophysitis and anti-rabphilin-3A antibody with pulmonary sarcoidosis
To explore the clinical significance of anti-rabphillin-3A antibody for the differential diagnosis of lymphocytic panhypophysitis.
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Article
Open AccessGalectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins
Autophagy has been linked to a wide range of functions, including a degradative process that defends host cells against pathogens. Although the involvement of autophagy in HBV infection has become apparent, it...
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Article
Open AccessThe Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers
Dickkopf1 (DKK1) is overexpressed in various cancers and promotes cancer cell proliferation by binding to cytoskeleton-associated protein 4 (CKAP4). However, the mechanisms underlying DKK1 expression are poorl...
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Article
Open AccessOne‐year clinically important deterioration and long‐term clinical course in Japanese patients with COPD: a multicenter observational cohort study
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with a complex progression of many clinical presentations, and clinically important deterioration (CID) has been proposed in the Western ...
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Article
Open AccessVariation of human norovirus GII genotypes detected in Ibaraki, Japan, during 2012–2018
Human norovirus (HuNoV) is the major cause of viral acute gastroenteritis for all age groups in various countries. HuNoV GII in particular accounted for the majority of norovirus outbreaks, among which GII.4 c...
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Article
Open AccessPIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed ...
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Article
Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug
Aberrant expression of the secretory protein Dickkopf1 (DKK1) is associated with poor prognosis of esophageal squamous cell carcinoma (ESCC), but the underlying mechanism of how DKK1 is involved in aggressiven...
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Article
Diagnostic Value of Vascular Endothelial Growth Factor, Transforming Growth Factor-β, Interleukin-8, and the Ratio of Lactate Dehydrogenase to Adenosine Deaminase in Pleural Effusion
We studied the diagnostic value of cytokines, including vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and interleukin-8 (IL-8), and the ratio of lactate dehydrogenase (LDH) t...
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Reference Work Entry In depth
Inflammatory Mediators in Neonatal Asphyxia and Infection
Inflammatory mediators, such as inflammatory cytokines, are closely associated with neonatal diseases, including neonatal asphyxia (NA) and infection. The pathophysiology of NA may be mainly responsible for is...
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Article
Open AccessSimultaneous oral administration of Salmonella Infantis and S. Typhimurium in chicks
To confirm the hypothesis that Salmonella enterica subspecies enterica serovar (S.) Infantis has higher basic reproductive rates in chicks compared with other Salmonella serovars, 1-day-old specific-pathogen-free...
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Article
Open AccessPoly I:C induces collective migration of HaCaT keratinocytes via IL-8
Delayed wound healing reduces the quality of life (QOL) of patients. Thus, understanding the mechanism of wound healing is indispensable for better management. However, the role of innate immunity in wound hea...
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Article
Open AccessThe tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein
Diverse cellular proteins and RNAs are tightly regulated in their subcellular localization to exert their local function. Here we report that the tumour suppressor adenomatous polyposis coli protein (APC) dire...
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Article
Open AccessMolecular evolution of the capsid gene in human norovirus genogroup II
Capsid protein of norovirus genogroup II (GII) plays crucial roles in host infection. Although studies on capsid gene evolution have been conducted for a few genotypes of norovirus, the molecular evolution of ...
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Living Reference Work Entry In depth
Inflammatory Mediators in Neonatal Asphyxia and Infection
Inflammatory mediators, such as inflammatory cytokines, are closely associated with neonatal diseases, including neonatal asphyxia (NA) and infection. The pathophysiology of NA may be mainly responsible for is...
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Article
Open AccessMolecular Evolution of the Capsid Gene in Norovirus Genogroup I
We studied the molecular evolution of the capsid gene in all genotypes (genotypes 1–9) of human norovirus (NoV) genogroup I. The evolutionary time scale and rate were estimated by the Bayesian Markov chain Mon...
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Article
Open AccessMolecular evolution of haemagglutinin (H) gene in measles virus
We studied the molecular evolution of the haemagglutinin (H) gene (full length) in all genotypes (24 genotypes, 297 strains) of measles virus (MeV). The gene’s evolutionary timescale was estimated by the Bayesian...
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Article
Open AccessASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction
APOBEC3G (A3G) is an innate antiviral restriction factor that strongly inhibits the replication of human immunodeficiency virus type 1 (HIV-1). An HIV-1 accessory protein, Vif, hijacks the host ubiquitin–prote...
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Article
Open AccessMolecular evolution of the VP1, VP2 and VP3 genes in human rhinovirus species C
Human rhinovirus species C (HRV-C) was recently discovered and this virus has been associated with various acute respiratory illnesses (ARI). However, the molecular evolution of the major antigens of this viru...
