24 Result(s)

Article

Lesional infiltration of receptor activator of nuclear factor-κB ligand⁺ cells in experimental autoimmune neuritis rats

Experimental autoimmune neuritis (EAN) is a T cell-mediated autoimmune demyelinating inflammatory disease of the peripheral nervous system. Receptor activator of NF-κB ligand (RANKL), a member of the tumor nec...

Ying Yin, Hermann J. Schluesener, Zhi-Yuan Zhang, Zhiren Zhang in Neurological Sciences (2013)

Article

Nanosilver: application and novel aspects of toxicology

Nanomaterials are a challenge to toxicology. The high diversity of novel materials and products will require extensive expertize for evaluation and regulatory efforts. Nanomaterials are of substantial scientif...

Jan K. Schluesener, Hermann J. Schluesener in Archives of Toxicology (2013)

Article

Doxycycline Attenuates Peripheral Inflammation in Rat Experimental Autoimmune Neuritis

Experimental autoimmune neuritis (EAN) is a T cell-mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system and widely-used animal model of human inflammatory demyelinating polyr...

Chenju Yi, Zhiyuan Zhang, Wei Wang, Caroline Zug… in Neurochemical Research (2011)

Article

Antimicrobial Peptides in the Brain

Antimicrobial peptides (AMPs) are an evolutionarily conserved component of the innate immune system of many species. The brain is an immunologically privileged organ but can produce a robust immune response ag...

Yanhua Su, Kai Zhang, Hermann J. Schluesener in Archivum Immunologiae et Therapiae Experim… (2010)

Article

Apoptosis induced by titanium dioxide nanoparticles in cultured murine microglia N9 cells

Owing to the rapidly increasing output of nano-scale titanium dioxide (TiO₂) particles, their potential risk for central nerve system (CNS) has elicited much concern recently. Microglia is the resident macrophage...

**aoBo Li, ShunQing Xu, ZhiRen Zhang, Hermann J. Schluesener in Chinese Science Bulletin (2009)

Article

Dexamethasone suppresses infiltration of RhoA⁺ cells into early lesions of rat traumatic brain injury

Inflammatory cell infiltration is a major part of secondary tissue damage in traumatic brain injury (TBI). RhoA is an important member of Rho GTPases and is involved in leukocyte migration. Inhibition of RhoA ...

Zhiren Zhang, Uwe Fauser, Hermann J. Schluesener in Acta Neuropathologica (2008)

Article

Reply: p43 and endothelial monocyte activation polypeptide II (EMAP-II) in CNS pathology

Liang-Hao Guo, Zhi-Yuan Zhang, Hermann J. Schluesener in Acta Neuropathologica (2007)

Article

Dexamethasone attenuates early expression of three molecules associated with microglia/macrophages activation following rat traumatic brain injury

Corticosteroids have been used in the treatment of human traumatic brain injury (TBI), which is a leading cause of death and disability, but their efficiency is still a matter of debate. Dexamethasone was cons...

Zhiyuan Zhang, Zhiren Zhang, Matthias Artelt, Michael Burnet… in Acta Neuropathologica (2007)

Article

Acute but not chronic stimulation of glial cells in rat spinal cord by systemic injection of lipopolysaccharide is associated with hyperalgesia

We have analyzed development of mechanical hyperalgesia after repeated systemic lipopolysaccharide (LPS) injections and correlated these findings with stimulation of astrocytes and microglia in spinal cord. Ma...

Liang-Hao Guo, Hermann J. Schluesener in Acta Neuropathologica (2006)

Article

Molecular addresses of tumors: selection by in vivo phage display

In vivo phage display has been used extensively to screen for novel targets of tumor therapy. Phage display peptide libraries can express random peptides or protein fragments and the aim of phage display is to id...

**ao-Bo Li, Hermann J. Schluesener… in Archivum Immunologiae et Therapiae Experim… (2006)

Article

Therapeutic effects of cisplatin on rat experimental autoimmune encephalomyelitis

Introduction: Experimental autoimmune encephalomyelitis (EAE) is a prototypic Th1-mediated autoimmune inflammatory disease of the central nervous system (CNS), and serves as a model for t...

**ao-Bo Li, Hermann J. Schluesener in Archivum Immunologiae et Therapiae Experimentalis (2006)

Article

Uptake, cellular distribution and novel cellular binding proteins of immunostimulatory CpG oligodeoxynucleotides in glioblastoma cells

Glioblastomas are the most malignant and most frequent brain tumors and exciting targets of gene and immunotherapy. Despite rapid development of experimental therapy little is known about the cellular behaviou...

Zhiren Zhang, Toni Weinschenk… in Molecular and Cellular Biochemistry (2005)

Article

Expression and release of CD14 in astrocytic brain tumors

CD14 is a membrane-bound lipopolysaccharide receptor or, lacking the glycosylphosphatidylinositol anchor, is secreted to modulate cellular and humoral immune response by interacting directly with T and B cells...

Martin H. Deininger, Richard Meyermann, Hermann J. Schluesener in Acta Neuropathologica (2003)

Article

Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease

Cyclooxygenases (COXs) mediate inflammation, immunomodulation, blood flow, apoptosis, and fever in various diseases of the brain. Whereas COX-2 is cytokine inducible, COX-1 is expressed by macrophages/microgli...

Martin H. Deininger, Kubrom Bekure-Nemariam… in Journal of Molecular Neuroscience (2003)