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  1. Article

    Open Access

    TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma

    The ubiquitin-proteasome system is a vital protein degradation system that is involved in various cellular processes, such as cell cycle progression, apoptosis, and differentiation. Dysregulation of this syste...

    Donghee Kang, Hyun Jung Hwang, Yurim Baek, Jee Young Sung in Cell Death & Disease (2024)

  2. Article

    Open Access

    Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ–p53–p21 signaling pathway

    Acyl-CoA thioesterase 7 (ACOT7) is a major isoform of the ACOT family that catalyzes hydrolysis of fatty acyl-CoAs to free fatty acids and CoA-SH. However, canonical and non-canonical functions of ACOT7 remain...

    Seung Hee Jung, Hyung Chul Lee, Hyun Jung Hwang, Hyun A Park in Cell Death & Disease (2017)

  3. Article

    Open Access

    Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase

    Radiotherapy represents the most effective non-surgical modality in cancer treatment. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression, and are involved in many biological processes a...

    Hyung Chul Lee, Nam-Gu Her, Donghee Kang, Seung Hee Jung in Cell Death & Disease (2017)