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Article
Open AccessTRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma
The ubiquitin-proteasome system is a vital protein degradation system that is involved in various cellular processes, such as cell cycle progression, apoptosis, and differentiation. Dysregulation of this syste...
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Article
A novel long noncoding RNA Linc-ASEN represses cellular senescence through multileveled reduction of p21 expression
Long noncoding RNAs (lncRNAs) regulating diverse cellular processes implicate in many diseases. However, the function of lncRNAs in cellular senescence remains largely unknown. Here we identify a novel long in...
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Article
Induction of p53-mediated senescence is essential for the eventual anticancer therapeutic effect of RH1
RH1 (2, 5-diaziridinyl-3-(hydroxymethy)-6-methyl-1, 4-benzoquinone) is a bioreductive anticancer drug. The mechanism underlying its therapeutic properties has not yet been elucidated. In this study, we aimed t...
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Article
Open AccessmTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
Loss of PTEN, the major negative regulator of the PI3K/AKT pathway induces a cellular senescence as a failsafe mechanism to defend against tumorigenesis, which is called PTEN-loss-induced cellular senescence (...
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Article
Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues
Cellular senescence refers to an irreversible growth arrest that is triggered by various intrinsic and extrinsic stresses. Many recent studies have demonstrated that cellular senescence plays a crucial role in...
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Article
Open AccessAcyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ–p53–p21 signaling pathway
Acyl-CoA thioesterase 7 (ACOT7) is a major isoform of the ACOT family that catalyzes hydrolysis of fatty acyl-CoAs to free fatty acids and CoA-SH. However, canonical and non-canonical functions of ACOT7 remain...
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Article
Open AccessRadiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase
Radiotherapy represents the most effective non-surgical modality in cancer treatment. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression, and are involved in many biological processes a...
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Article
Open AccessNQO1 inhibits proteasome-mediated degradation of HIF-1α
Overexpression of NQO1 is associated with poor prognosis in human cancers including breast, colon, cervix, lung and pancreas. Yet, the molecular mechanisms underlying the pro-tumorigenic capacities of NQO1 hav...
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Article
Open AccessDocetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia
HIF-1 (hypoxia-inducible factor-1) regulates the expression of more than 70 genes involved in angiogenesis, tumor growth, metastasis, chemoresistance, and radioresistance. Thus, there is growing interest in us...
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Article
Open AccessNQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation
Oxygen and glucose deprivation (OGD) due to insufficient blood circulation can decrease cancer cell survival and proliferation in solid tumors. OGD increases the intracellular [AMP]/[ATP] ratio, thereby activa...
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Article
Open AccessHS-173, a Novel PI3K Inhibitor, Attenuates the Activation of Hepatic Stellate Cells in Liver Fibrosis
Hepatic stellate cells (HSCs) are the primary source of matrix components in liver disease such as fibrosis. Phosphatidylinositol 3-kinase (PI3K) signaling in HSCs has been shown to induce fibrogenesis. In thi...
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Article
Open AccessMetformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells
The anti-cancer effects of metformin, the most widely used drug for type 2 diabetes, alone or in combination with ionizing radiation were studied with MCF-7 human breast cancer cells and FSaII mouse fibrosarco...
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Article
Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells
Histone deacetylase (HDAC) plays an important role in cancer onset and progression. Therefore, inhibition of HDAC offers potential as an effective cancer treatment regimen. CG200745, (E)-N1-(3-(dimethylamino)prop...
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Article
Open Accessβ-Lapachone suppresses radiation-induced activation of nuclear factor-κB
Anticancer effects of β-lapachone (β-lap) are due to generation of ROS and metabolic catastrophes as a result of NAD(P)H:quinone oxidoreductase (NQO1)-mediated futile cycling between the oxidized and reduced f...
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Article
pH-sensitivity control of PEG-poly(β-amino ester) block copolymer micelle
Poly(ethylene glycol) methyl ether (PEG)-poly(β-amino ester) (PAE) block copolymers were synthesized using a Michael-type step polymerization, and the construction of pH-sensitive polymeric micelles (PM) inves...
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Article
Transferrin-conjugated liposome/IL-12 pDNA complexes for cancer gene therapy in mice
Transferrin (Tf) has been used as a targeting ligand for delivering liposome/interleukin-12 (IL-12) pDNA complexes to cancer cells mostly due to the greater number of transferrin receptors (TfR) found on tumor ce...
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Article
Modulation of poly(β-amino ester) pH-sensitive polymers by molecular weight control
The main objective of this study was to modulate pH-sensitive polymers(poly(β-amino esters)) by controlling their molecular weight during their synthesis. These pH-sensitive and biodegradable polymers were syn...
