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Article
Impact of HER2 status on clinicopathological characteristics and pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer
HER2-low triple-negative breast cancer (TNBC) accounted for up to 34%–39% of primary TNBC and 22.2%–32% of metastatic TNBC. Our study aims to explore the relationship between HER2 expression and clinicopatholo...
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Article
Method for rapid warning and activity concentration estimates in online water γ-spectrometry systems
Online γ-spectrometry systems for inland waters, most of which extract samples in situ and in real time, are able to produce reliable activity concentration measurements for waterborne radionuclides only when ...
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Article
Multimorbidity patterns and health-related quality of life among community-dwelling older adults: evidence from a rural town in Suzhou, China
The high prevalence of multimorbidity in aging societies has posed tremendous challenges to the healthcare system. The aim of our study was to comprehensively assess the association of multimorbidity patterns ...
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Article
Open AccessGraphene nanomechanical vibrations measured with a phase-coherent software-defined radio
Software-defined radios (SDRs) are radio frequency transceivers designed to facilitate digital signal processing through the use of vast libraries of open-source software. Here, we assemble a simple data acqui...
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Article
Open AccessGrape Seed Proanthocyanidins Protect Pancreatic β Cells Against Ferroptosis via the Nrf2 Pathway in Type 2 Diabetes
Pancreatic β cell damage is the primary contributor to type 2 diabetes mellitus (T2DM); however, the underlying mechanism remains nebulous. This study explored the role of ferroptosis in pancreatic β cell dama...
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Article
Open AccessTesting, diagnosis, and treatment following the implementation of a program to provide dried blood spot testing for HIV and hepatitis C infections: the NSW DBS Pilot
Dried blood spot (DBS) testing provides an alternative to phlebotomy and addresses barriers to accessing healthcare experienced by some key populations. Large-scale evaluations of DBS testing programs are need...
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Article
Small-molecule autocatalysis drives compartment growth, competition and reproduction
Sustained autocatalysis coupled to compartment growth and division is a key step in the origin of life, but an experimental demonstration of this phenomenon in an artificial system has previously proven elusiv...
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Article
The impact of climate change and human activities on the change in the net primary productivity of vegetation—taking Sichuan Province as an example
Vegetation is an essential component of terrestrial ecosystems, influenced by climate change and human activities. Quantifying the relative contributions of climate change and human activities to vegetation dy...
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Article
Open AccessMuc2 mucin o-glycosylation interacts with enteropathogenic Escherichia coli to influence the development of ulcerative colitis based on the NF-kB signaling pathway
Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine characterized by a compromised intestinal epithelial barrier. Mucin glycans are crucial in preserving barrier function during bacteria...
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Article
Prevalent falls, fall frequencies and health-related quality of life among community-dwelling older Chinese adults
Fall is a serious health hazard to older adults. The aim of our study was to investigate the relationship between falls and health-related quality of life (HRQOL) in mainland China.
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Article
Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing
Despite intensive studies in modeling neuropsychiatric disorders especially autism spectrum disorder (ASD) in animals, many challenges remain. Genetic mutant mice have contributed substantially to the current ...
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Article
Spatial distribution of landslide shape induced by Luding Ms6.8 earthquake, Sichuan, China: case study of the Moxi Town
Landslides induced by the 2022 Luding Ms 6.8 earthquake mainly occurred in the Moxi Town, the Detuo Town, and the Wanggang** County, causing serious casualties and property losses. Among these places, the Moxi ...
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Article
A real-time processing method for GB-SAR monitoring data by using the dynamic Kalman filter based on the PS network
Ground-based synthetic aperture radar (GB-SAR) has been widely used in the safety monitoring of slopes, dams, and buildings due to its high precision, large coverage area, and fast image acquisition. The real-...
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Article
Ultrasound-guided erector spinae plane block for postoperative analgesia in Chinese patients undergoing laparoscopic cholecystectomy: a double-blind randomized controlled trial
Pain management after laparoscopic cholecystectomy (LC) is a main concern for Chinese clinicians. This study aims to explore the effect of erector spinae plane block (ESPB) on the postoperative analgesia of pa...
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Chapter and Conference Paper
Improving Fine-Grained Emotion Control and Transfer with Gated Emotion Representations in Speech Synthesis
Fine-grained emotion strength control and prediction is recently studied in text-to-speech to adjust local emotion intensity in an utterance. Due to the lack of fine-grained emotion strength labelling data, em...
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Chapter and Conference Paper
Automatic Stress Annotation and Prediction for Expressive Mandarin TTS
The current text-to-speech technique has developed to a close-to-human state, and more research interest has been paid to highly expressive and more controllable speech synthesis. Stress detection and modeling...
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Article
Open AccessAPE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas
Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is the main risk factor for the development of Barrett’s esophagus (BE),...
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Article
Open AccessSynthesis of aryldifluoromethyl aryl ethers via nickel-catalyzed suzuki cross-coupling between aryloxydifluoromethyl bromides and boronic acids
As a unique organofluorine fragment, gem-difluoromethylated motifs have received widespread attention. Here, a convenient and efficient synthesis of aryldifluoromethyl aryl ethers (ArCF2OAr’) was established via ...
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Article
Composition Evolution of Mo–Si–O Films Under Heat Treatment
Molybdenum disilicide (MoSi2) films were synthesized by heat treatment of a Si/Mo/Si and Mo/Si sample systems at different temperatures in air. The onset temperature of MoSi2 formation started from 350 ℃ and cont...
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Article
Open AccessFree charge photogeneration in a single component high photovoltaic efficiency organic semiconductor
Organic photovoltaics (OPVs) promise cheap and flexible solar energy. Whereas light generates free charges in silicon photovoltaics, excitons are normally formed in organic semiconductors due to their low diel...
