29 Result(s)
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Hellmut G. Augustin
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Article
Open AccessLung endothelium exploits susceptible tumor cell states to instruct metastatic latency
In metastasis, cancer cells travel around the circulation to colonize distant sites. Due to the rarity of these events, the immediate fates of metastasizing tumor cells (mTCs) are poorly understood while the r...
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Open AccessThe angiopoietin receptor Tie2 is atheroprotective in arterial endothelium
Leukocytes and resident cells in the arterial wall contribute to atherosclerosis, especially at sites of disturbed blood flow. Expression of endothelial Tie1 receptor tyrosine kinase is enhanced at these sites...
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Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
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Open AccessVisceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
Disruption of lymphatic lipid transport is linked to obesity and type 2 diabetes (T2D), but regulation of lymphatic vessel function and its link to disease remain unclear. Here we show that intestinal lymphati...
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Open AccessAngiodiversity and organotypic functions of sinusoidal endothelial cells
‘Angiodiversity’ refers to the structural and functional heterogeneity of endothelial cells (EC) along the segments of the vascular tree and especially within the microvascular beds of different organs. Organo...
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Open AccessNASH limits anti-tumour surveillance in immunotherapy-treated HCC
Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stra...
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Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk
Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback respo...
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Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, w...
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Open AccessConsensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angio...
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T-lymphocyte profiles differ between keratoacanthomas and invasive squamous cell carcinomas of the human skin
T-lymphocytes are involved in tumor progression and regression. Actinic keratoses (AK) are atypical proliferations of keratinocytes of the skin. Some AK progress into invasive cutaneous squamous cell carcinoma...
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Preclinical mouse solid tumour models: status quo, challenges and perspectives
A systematic survey of 949 studies published in 2016 was conducted to quantitatively review the status quo of mouse tumour model experimentation.
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Open AccessPericyte-expressed Tie2 controls angiogenesis and vessel maturation
The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expr...
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Open AccessPlastic roles of pericytes in the blood–retinal barrier
The blood–retinal barrier (BRB) consists of tightly interconnected capillary endothelial cells covered with pericytes and glia, but the role of the pericytes in BRB regulation is not fully understood. Here, we...
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Tumor Vessel Associated-Pericytes
In blood vessels, the crosstalk between vascular endothelial cells and mural cells (pericytes/vascular smooth muscle cells) play a central role in the regulation of vascular formation, maturation, remodeling, ...
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Spheroid-based human endothelial cell microvessel formation in vivo
The study of angiogenic endothelial cells (ECs) has in recent years greatly stimulated multiple fields of vascular biology research. A number of cellular models and numerous complex developmental, manipulatory...
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Tension in the vasculature
Blood vessels arise from progenitor cells, grow and branch by sprouting from preexisting vessels and remodel by splitting longitudinally. A new study proposes an additional mechanism. It seems that vasculariza...
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The role of the Angiopoietins in vascular morphogenesis
The Angiopoietin/Tie system acts as a vascular specific ligand/receptor system to control endothelial cell survival and vascular maturation. The Angiopoietin family includes four ligands (Angiopoietin-1, Angio...
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Blood vessels kept quiet
Tumours must get their oxygen fix, otherwise invasive tumour growth and spread can occur. One way of quelling oxygen-deprived tumours might be through manipulating the oxygen sensor PHD2.
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Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
The assembly of a functional vascular system requires coordinated signalling between various growth factors and receptors. The Tie receptors and their angiopoi...
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Open AccessEphrin-B2 expression critically influences Nipah virus infection independent of its cytoplasmic tail
Cell entry and cell-to-cell spread of the highly pathogenic Nipah virus (NiV) requires binding of the NiV G protein to cellular ephrin receptors and subsequent NiV F-mediated fusion. Since expression levels of...
