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  1. Article

    Open Access

    Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3

    Spinocerebellar ataxia type 3 (SCA3) is caused by the expansion of a polyglutamine (polyQ) repeat in the protein ataxin-3 which is involved in susceptibility to mild oxidative stress induced neuronal death. He...

    Yu-Ling Wu, Jui-Chih Chang, Wei-Yong Lin, Chien-Chun Li, Mingli Hsieh… in Scientific Reports (2017)

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    Article

    Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells

    Matrix metalloproteinase-9 (MMP-9) plays a crucial role in tumor metastasis. Previous studies showed that polyunsaturated fatty acids exhibit an anti-cancer effect in various human carcinoma cells, but the eff...

    Haw-Wen Chen, Che-Yi Chao, Li-Lin Lin, Chia-Yang Lu, Kai-Li Liu… in Archives of Toxicology (2013)

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    Article

    Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes

    Chrysin, apigenin, and luteolin are flavones that differ in their number of hydroxyl groups in the B ring. In this study, we investigated the protection by chrysin, apigenin, and luteolin against tert-butyl hydro...

    Chin-Shiu Huang, Chong-Kuei Lii, Ai-Hsuan Lin, Yu-Wen Yeh… in Archives of Toxicology (2013)

  4. No Access

    Article

    Gamma-Linolenic Acid Inhibits Inflammatory Responses by Regulating NF-κB and AP-1 Activation in Lipopolysaccharide-Induced RAW 264.7 Macrophages

    Gamma linolenic acid (GLA) is a member of the n-6 family of polyunsaturated fatty acids and can be synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase. The therapeutic values of GLA supplement...

    Cheng-Sue Chang, Hai-Lun Sun, Chong-Kuei Lii, Haw-Wen Chen, Pei-Yin Chen… in Inflammation (2010)

  5. No Access

    Protocol

    Measurement of S-Glutathionated Hemoglobin in Human Erythrocytes by Isoelectric Focusing Electrophoresis

    Protein thiol groups are susceptible to oxidation by reactive oxygen species (1). The occurrence of a specific thiol modification named protein S-glutathionation has been proposed to protect proteins from oxidati...

    Haw-Wen Chen, Chong-Kuei Lii in Oxidative Stress Biomarkers and Antioxidant Protocols (2002)

  6. No Access

    Article

    Vitamin E protection of cell morphology under oxidative stress is related to cytoskeletal proteins in rat hepatocytes

    A significant change in cell morphology was observed in hepatocytes treated with t-butyl hydroperoxide (t-BH). This morphological change of multiple bleb formation on cell plasma membranes was related to cell ...

    Jyh-Huang Kuo, Haw-Wen Chen, Rong-Ghi R. Chou, C.-K. Lii in Archives of Toxicology (1997)

  7. No Access

    Article

    Glutathione and glutathione-related enzyme activities of male and female rat hepatocytes under various culture conditions

     The effect of culture medium on glutathione (GSH) dependent detoxification defence system of primary cultured hepatocyte from either male or female rats was studied. Intracellular reduced (GSH) and oxidized g...

    C.-K. Lii, Shih-Tsung Wang, Haw-Wen Chen, Lee-Yan Sheen in Archives of Toxicology (1996)

  8. No Access

    Article

    Gender and dietary fat affect α-tocopherol status in F344/N rats

    For four weeks, groups of eight male and eight female F344/N rats were fed diets containing 15.5, 20, 30 or 40% of energy (en%) as fat. The fat was composed of corn oil and beef tallow with 9 en% from linoleat...

    Haw-Wen Chen, Laura R. Cook, Suzanne Hendrich in Lipids (1992)