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  1. No Access

    Article

    A New Labdane Derivative from the Bark of Chamaecyparis obtusa var. formosana

    A new labdane derivative, chamaecyparisin A (1), was isolated from the methanol extract of the bark of Chamaecyparis obtusa var. formosana. Its structure was established by spectroscopic analyses including 1D and...

    Ming-Jen Cheng, Wen-Wei Lin, Che-Yi Chao, Yu-Chang Chen… in Chemistry of Natural Compounds (2023)

  2. No Access

    Article

    Seco-Abietanoids from Cryptomeria japonica and Their Inhibitory Activity Toward Xanthine Oxidase

    A new seco-abietanoid, 12-methoxy-7-oxo-6,7-secoabieta-8,11,13-trien-6-oic acid (1), and a known seco-abietanoid,12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (2), were isolated from the methanol extract of t...

    Chi-I Chang, Cheng-Chi Chen, Horng-Huey Ko, Jih-Jung Chen… in Chemistry of Natural Compounds (2022)

  3. Article

    Open Access

    Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan

    Asthma is an inflammatory disease and interleukin 12 (IL-12) may play a regulatory role in allergen-induced inflammation. The aim of this study was to investigate the association of polymorphisms in IL-12A/IL-12B

    Te-Chun Shen, Chia-Wen Tsai, Wen-Shin Chang, Shengyu Wang… in Scientific Reports (2017)

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  4. Article

    Open Access

    Effect of wild bitter gourd treatment on inflammatory responses in BALB/c mice with sepsis

    Background/Introduction: Wild bitter gourd (Momordica charantia L. var. abbreviate Seringe) common vegetable in Asia, is used in traditional medicine to treat various diseases, including inflammation. Extant l...

    Shin-You Ciou, Cheng-Chin Hsu, Yueh-Hsiung Kuo, Che-Yi Chao in BioMedicine (2014)

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  5. No Access

    Article

    Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells

    Matrix metalloproteinase-9 (MMP-9) plays a crucial role in tumor metastasis. Previous studies showed that polyunsaturated fatty acids exhibit an anti-cancer effect in various human carcinoma cells, but the eff...

    Haw-Wen Chen, Che-Yi Chao, Li-Lin Lin, Chia-Yang Lu, Kai-Li Liu… in Archives of Toxicology (2013)

  6. Article

    Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARα in bitter gourd (Momordica charantia L.)

    Bitter gourd (Momordica charantia L.) is a common vegetable in Asia that has been used in traditional medicine for the treatment of Diabetes. PPARs are ligand-dependent transcription factors that belong to the st...

    Chia-Ying Chuang, Chin Hsu, Che-Yi Chao, Yung-Shung Wein… in Journal of Biomedical Science (2006)

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  7. No Access

    Article

    Bitter gourd(Momordica charantia) extract activates peroxisome proliferator-activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells

    Peroxisome proliferator-activated receptor α (PPARα) is a ligand-dependent transcription factor that regulates the expression of genes involved in lipid metabolism and transport. Ligands/activators of PPARα, l...

    Che-Yi Chao, Ching-jang Huang PhD in Journal of Biomedical Science (2003)