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Article
Biotechnological aspects of the production of human pro-kallikrein using the AcNPV-baculovirus-expression system
We have investigated large scale production processes (up to 2 liters) of recombinant proteins using the baculovirus expression system in order to optimize the product yields. Experiments using cell lines ofSpodo...
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Article
Replication of centromeric heterochromatin in mouse fibroblasts takes place in early, middle, and late S phase
The replication of eukaryotic chromosomes takes place throughout S phase, but little is known how this process is organized in space and time. Early and late replicating chromosomal domains appear to localize ...
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Article
Elucidating the principles of the molecular organization of heteropolymeric tight junction strands
Paracellular barrier properties of tissues are mainly determined by the composition of claudin heteropolymers. To analyze the molecular organization of tight junctions (TJ), we investigated the ability of clau...