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Article
Open AccessmiR-27b-3p reduces muscle fibrosis during chronic skeletal muscle injury by targeting TGF-βR1/Smad pathway
Fibrosis is a significant pathological feature of chronic skeletal muscle injury, profoundly affecting muscle regeneration. Fibro-adipogenic progenitors (FAPs) have the ability to differentiate into myofibrobl...
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Article
Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia
RNA-binding proteins (RBPs) are pivotal in acute myeloid leukaemia (AML), a lethal disease. Although specific phase separation-competent RBPs are recognized in AML, the effect of their condensate formation on ...
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Article
The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson’s disease via LCN2-dependent astrocyte senescence
Recent studies provide clues that astrocyte senescence is correlated with Parkinson’s disease (PD) progression, while little is known about the molecular basis for astrocyte senescence in PD. Here, we found th...
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Article
Open AccessNanofiber Composite Reinforced Organohydrogels for Multifunctional and Wearable Electronics
A nanofiber composite reinforced organohydrogel with multifunctionality is prepared.
The composite organohydrogel possesses ...
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Article
Open AccessPreventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2
Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2. Here we report that nelfinavir, an FDA approved drug for the treatment of HIV infec...
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Article
A multiplex real-time RT-PCR assay for the detection of H1, H2 and H3 subtype avian influenza viruses
Avian influenza viruses (AIVs) are influenza A viruses, of which subtypes H1, H2 and H3 are highly transmissible in poultry and have the risk of transmission to human as well. It is important to establish an a...
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Article
Modification of TiO2 by Er3+ and rGO enhancing visible photocatalytic degradation of arsanilic acid
As a typical wide band gap photocatalyst, titania (TiO2) cannot use the visible light and has fast recombination rate of photogenerated electron–hole pairs. Simultaneous introduction of erbium ion (Er3+) and grap...
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Article
Carbon Emission Characteristics of Resource-Based Cities in China
Resource-based cities generally have high energy consumption, high carbon emission, and high pollution. Exploring low-carbon planning of resource-based cities means great significance for promoting the low-car...
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Article
Rapid emergence of a PB2 D701N substitution during adaptation of an H9N2 avian influenza virus in mice
H9N2 avian influenza viruses (AIVs) have been isolated frequently from multiple avian species and, occasionally, from humans. To explore the potential molecular basis of cross-species transmission of H9N2 AIVs...
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Article
Open AccessSARS-CoV-2 N protein potentiates host NPM1-snoRNA translation machinery to enhance viral replication
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Article
Increased virulence of a novel reassortant H1N3 avian influenza virus in mice as a result of adaptive amino acid substitutions
In this study, a novel multiple-gene reassortant H1N3 subtype avian influenza virus (AIV) (A/chicken/Zhejiang/81213/2017, CK81213) was isolated in Eastern China, whose genes were derived from H1 (H1N3), H7 (H7...
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Article
Open Accessβ-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression
Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice, generally depending on the serotonergic system for drug treatment is unsatis...
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Article
Unusual global outbreak of monkeypox: what should we do?
Recently, monkeypox has become a global concern amid the ongoing COVID-19 pandemic. Monkeypox is an acute rash zoonosis caused by the monkeypox virus, which was previously concentrated in Africa. The re-emerge...
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Article
Thermal crosslinking synthesis of ethylene–vinyl acetate copolymer supported floating TiO2 photocatalyst: characterization and photocatalytic performance
Floating photocatalyst is of extensive interest due to easy recovery and efficient light harvest. Support materials largely determine the stability of floating photocatalysts and their synthesis complexity. Th...
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Article
Open AccessTranscription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content
Transcription Factor 4 (TCF4) has been associated with autism, schizophrenia, and other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the human neural tissue is poorly understood. He...
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Article
Open AccessAltered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy
Early-onset epileptic encephalopathies are severe disorders often associated with specific genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a neurodevelopmental condition characterize...
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Article
Open AccessAntigen-capture ELISA and immunochromatographic test strip to detect the H9N2 subtype avian influenza virus rapidly based on monoclonal antibodies
The H9N2 subtype of avian influenza virus (AIV) has become the most widespread subtype of AIV among birds in Asia, which threatens the poultry industry and human health. Therefore, it is important to establish...
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Article
Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis
The early stages of progressive degeneration of cartilage in articular joints are a hallmark of osteoarthritis. Healthy cartilage is lubricated by brush-like cartilage-binding nanofibres with a hyaluronan back...
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Article
Open AccessRetraction Note to: Methylene blue photochemical treatment as a reliable SARS-CoV-2 plasma virus inactivation method for blood safety and convalescent plasma therapy for COVID-19
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Article
Fabrication of methyl acrylate modified silica aerogel for capture of Cu2+ from aqueous solutions
With SiO2 gel as the main skeleton material, the surface modification with methyl acrylate (MA) and tetraethylenepentamine (TEPA) was carried out by Michael addition and substitution reaction, after CO2 supercrit...
