64 Result(s)

Article

Molecular subtypes of clear cell renal carcinoma based on PCD-related long non-coding RNAs expression: insights into the underlying mechanisms and therapeutic strategies

PCD-related long non-coding RNAs (PRLs) are rarely investigated in relation to clear cell renal carcinoma (ccRCC). As part of this study, we evaluated the immunological potential of PRL signatures as a biomark...

Han Wang, Yang Liu, Aifa Tang, **ansheng Zhang in European Journal of Medical Research (2024)

Article

The learning curve for minimally invasive Achilles repair using the “lumbar puncture needle and oval forceps” technique

An acute Achilles tendon rupture represents a common tendon injury, and its operative methods have been developed over the years. This study aimed to quantify the learning curve for the minimally invasive acut...

Yanrui Zhao, Hanzhou Wang, Binzhi Zhao, Shuo Diao… in BMC Musculoskeletal Disorders (2024)

Article

Endoscopic submucosal dissection versus surgery for T1b esophageal carcinoma: a single-center retrospective study

Endoscopic submucosal dissection (ESD) is a preferred treatment option for superficial esophageal squamous cell carcinoma (SESCC). However, only few studies compared long-term survival outcomes of ESD with sur...

Ting Zhang, Hanying Wang, Tian **, Zeyu Wu… in Journal of Cancer Research and Clinical On… (2024)

Article

The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice

Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifth metacarpals. In the previous publication, we first identified a heterozygous missense m...

Han Wang, **umin Chen, **aolu Meng, Yixuan Cao, Shirui Han, Keqiang Liu… in Bone Research (2024)

Article

Preoperative vascular heterogeneity based on dynamic susceptibility contrast MRI in predicting spatial pattern of locally recurrent high-grade gliomas

To investigate if spatial recurrence pattern is associated with patient prognosis, and whether MRI vascular habitats can predict spatial pattern.

Hanwei Wang, Linlan Zeng, Hao Wu, **g Tian, Huan **e, Letian Zhang… in European Radiology (2024)

Article

Free-hand technique of C7 pedicle screw insertion using a simply defined entry point without fluoroscopic guidance for cervical spondylotic myelopathy patients with C3 to C6 instrumented by lateral mass screws: a retrospective cohort study

Nowadays, both lateral mass screw (LMS) and pedicle screw were effective instrumentation for posterior stabilization of cervical spine. This study aims to evaluate the feasibility of a new free-hand technique ...

Jun Jiang, Chen-yu Song, Zheng-zheng Wu, Zuo-zhi **e, Bo Shi, Tao Xu… in BMC Surgery (2024)

Article

Optic Nerve Head Changes Measured by Swept Source Optical Coherence Tomography and Angiography in Patients with Intracranial Hypertension

This study explored the structural and microvascular changes in the optic nerve head (ONH) of patients with intracranial hypertension (IH) by using swept-source optical coherence tomography (SS-OCT)/OCT angiog...

Hang Wang, Le Cao, William Robert Kwapong, Guina Liu… in Ophthalmology and Therapy (2023)

Article

Identification of miRNAs Involved in Intracranial Aneurysm Rupture in Cigarette-Smoking Patients

Smoking is an independent risk factor for the formation and rupture of intracranial aneurysms (IA). However, the underlying mechanism remains unclear.

Hanbin Wang, Luxuan Wang, Yanli Tan, Chuan Fang, Chunhui Li… in Neurology and Therapy (2023)

Article

Rho-Kinase Inhibitors as Emerging Targets for Glaucoma Therapy

Glaucoma, the leading cause of irreversible blindness worldwide, is a chronic and progressive optic neuropathy characterized by damage to the optic and retinal nerve fiber layers, which can lead to permanent l...

Jun Wang, Hanke Wang, Yalong Dang in Ophthalmology and Therapy (2023)

Article

Identification of molecular subgroups and establishment of risk model based on the response to oxidative stress to predict overall survival of patients with lung adenocarcinoma

Oxidative stress is associated with the occurrence and development of lung cancer. However, the specific association between lung cancer and oxidative stress is unclear. This study aimed to investigate the rol...

Linzhuang Liu, Qinghua Hou, Baorong Chen, **yi Lai… in European Journal of Medical Research (2023)

Article

RIPK1 is aberrantly expressed in multiple B-cell cancers and implicated in the underlying pathogenesis

According to the latest epidemiology of the US, B-cell cancers account for > 3% of all new cancer cases and > 80% of non-Hodgkin lymphomas. However, the disease-modifying small molecular drug suitable for most...

Baoyu Wu, **gyu Li, Han Wang, Jianguo Liu, Jiayong Li, Fang Sun… in Discover Oncology (2023)

Article

Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition

Generating realistic virtual patients from a limited amount of patient data is one of the major challenges for quantitative systems pharmacology modeling in immuno-oncology. Quantitative systems pharmacology (...

Hanwen Wang, Theinmozhi Arulraj, Holly Kimko, Aleksander S. Popel in npj Precision Oncology (2023)

Article

The efficacy of medial meniscal posterior Root tear Repair with or without high tibial osteotomy: a systematic review

Medial meniscal posterior root tear (MMPRTs) is a common lesion of the knee joint, and repair surgery is a well-established treatment option. However, patients with obvious varus alignment are at an increased ...

Hangle Wang, Qian Man, Yitian Gao, Lingyi Xu… in BMC Musculoskeletal Disorders (2023)

Article

Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development

Qi Xu, Miaomiao **e, **aoxuan Liu, Heng Heng… in Signal Transduction and Targeted Therapy (2023)

Article

Screening and identification of key chromatin regulator biomarkers for ankylosing spondylitis and drug prediction: evidence from bioinformatics analysis

Ankylosing spondylitis (AS) is one of the most common immune-mediated arthritic diseases worldwide. Despite considerable efforts to elucidate its pathogenesis, the molecular mechanisms underlying AS are still ...

Han Wang, Hongbo **, Zhiyang Liu, Chengju Tan, Lin Wei… in BMC Musculoskeletal Disorders (2023)

Article

Decoding the key compounds and mechanism of Shashen Maidong decoction in the treatment of lung cancer

Lung cancer is a malignant tumour with the fastest increase in morbidity and mortality around the world. The clinical treatments available have significant side effects, thus it is desirable to identify alter...

Jieqi Cai, Yupeng Chen, Kexin Wang, Yi Li… in BMC Complementary Medicine and Therapies (2023)

Article

A novel predictive model of microvascular invasion in hepatocellular carcinoma based on differential protein expression

This study aims to construct and verify a nomogram model for microvascular invasion (MVI) based on hepatocellular carcinoma (HCC) tumor characteristics and differential protein expressions, and explore the cli...

Zhenglu Wang, Lei Cao, Jianxi Wang, Hanlin Wang, Tingting Ma… in BMC Gastroenterology (2023)

Article

Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis

Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer metastasis, accompanied with vast epigenetic changes. AMP-activated protein kinase (AMPK), a cellular energy sensor, plays regulatory r...

Ying Dong, Hao Hu, Xuan Zhang, Yunkai Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Risk factors for hyponatremia in acute exacerbation chronic obstructive pulmonary disease (AECOPD): a multicenter cross-sectional study

Hyponatremia is an independent predictor of poor prognosis, including increased mortality and readmission, in COPD patients. Identifying modifiable etiologies of hyponatremia may help reduce adverse events in ...

Min **ao, **aoyu Wang, Hanchao Wang, Fawang Du, Yu Yao… in BMC Pulmonary Medicine (2023)

Article

Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1

Lung adenocarcinoma is the major subtype of lung cancer, accounting for approximately 40% of lung cancers. During clinical treatment, the emergence of chemotherapy resistance seriously affects the effectivenes...

Jianjun Li, Yaqi Kou, **aohan Zhang, Xuechun **ao, Yang Ou, Lixia Cao… in Discover Oncology (2022)