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Article
AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility
Tobacco carcinogens metabolism-related genes (TCMGs) could generate reactive metabolites of tobacco carcinogens, which subsequently contributed to multiple diseases. However, the association between genetic va...
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Article
Sporocarp-associated fungal co-occurrence networks in a corn field revealed by long-read high-throughput sequencing
We identified a sporocarp as Agrocybe dura growing next to a living corn using PacBio sequencing.
The mycoparasitism of Tric...
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Article
The core phoD-harboring bacteria promote wheat phosphorus uptake by enhancing alkaline phosphatase activity under long-term fertilization
Soil pH was the key factor influencing the phoD-harboring bacterial networks.
Identification of a cluster positively linked ...
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Article
Biogeographic patterns and drivers of soil viromes
Viruses are crucial in sha** soil microbial functions and ecosystems. However, studies on soil viromes have been limited in both spatial scale and biome coverage. Here we present a comprehensive synthesis of...
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Article
Open AccessMacrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice
Hypercholesterolemia and vascular inflammation are key interconnected contributors to the pathogenesis of atherosclerosis. How hypercholesterolemia initiates vascular inflammation is poorly understood. Here we...
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Article
Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China
Plant and fungal species interactions drive many essential ecosystem properties and processes; however, how these interactions differ between aboveground and belowground habitats remains unclear at large spati...
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Article
Open AccessRisk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations
The genetic architectures of colorectal cancer are distinct across different populations. To date, the majority of polygenic risk scores (PRSs) are derived from European (EUR) populations, which limits their a...
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Article
Combined application of organic manure and chemical fertilizers stabilizes soil N-cycling microflora
• The abundance of N-cycling genes differently responded to NPK application.
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Article
Soil biodiversity supports the delivery of multiple ecosystem functions in urban greenspaces
While the contribution of biodiversity to supporting multiple ecosystem functions is well established in natural ecosystems, the relationship of the above- and below-ground diversity with ecosystem multifuncti...
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Article
High-density lipoprotein, low-density lipoprotein and triglyceride levels and upper gastrointestinal cancers risk: a trans-ancestry Mendelian randomization study
This study was conducted to explore the causal associations of high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglyceride (TG) with the risk of upper gastrointestinal cancers (esophageal ca...
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Article
Genetic variants in choline metabolism pathway are associated with the risk of bladder cancer in the Chinese population
Choline metabolism alteration is considered as a metabolic hallmark in cancer, reflecting the complex interactions between carcinogenic signaling pathways and cancer metabolism, but little is known about wheth...
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Article
Evaluation of genetic variants in nucleosome remodeling and deacetylase (NuRD) complex subunits encoding genes and gastric cancer susceptibility
Epigenetic complex NuRD (nucleosome remodeling and deacetylase) engages in a range of basic cellular processes, including chromatin modification. Changes in the activity of NuRD complex can influence gastric c...
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Article
Open AccessExosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3–eIF3h interaction
Exosomes have emerged as vital biomarkers of multiple cancers and contain abundant circular RNAs (circRNAs). However, the potential for exosomal circRNAs to be used in diagnostics and their molecular mechanism...
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Article
Editorial: Rhizosphere microbiome special issue
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Article
Functional variants of RPS6KB1 and PIK3R1 in the autophagy pathway genes and risk of bladder cancer
Autophagy plays a critical role in cancer, since it can either suppress tumorigenesis by inhibiting cancer cell survival, or facilitate tumorigenesis by promoting cancer cell proliferation and tumor growth. Ho...
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Article
Special Issue on Soil Microbial Ecology
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Article
Strong partitioning of soil bacterial community composition and co-occurrence networks along a small-scale elevational gradient on Zi** Mountain
The elevational distributions of bacterial communities in natural mountain forests, especially along large elevational gradients, have been studied for many years. However, the distributional patterns that und...
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Article
The spatial variation of soil bacterial community assembly processes affects the accuracy of source tracking in ten major Chinese cities
Urban soils harbor billions of bacterial cells and millions of species. However, the distribution patterns and assembly processes of bacterial communities remain largely uncharacterized in urban soils. It is a...
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Article
Genetic variations in the CTLA-4 immune checkpoint pathway are associated with colon cancer risk, prognosis, and immune infiltration via regulation of IQCB1 expression
The programmed cell death-1 (PD-1)/cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) immune checkpoint pathways serve as targets of immunotherapy for colorectal cancer. However, the associations between gen...
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Article
Identification of low-frequency variants of UGT1A3 associated with bladder cancer risk by next-generation sequencing
Although genome-wide association studies (GWASs) have successfully revealed many common risk variants for bladder cancer, the heritability is still largely unexplained. We hypothesized that low-frequency varia...
