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Article
Open AccessInvestigation of clinicopathological characteristics and prognosis of abdominal Desmoid tumors
Abdominal desmoid tumors (DTs) are rare soft-tissue neoplasms known for their relatively high local recurrence rate. This study aims to elucidate the clinicopathological features and investigate prognostic fac...
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Article
Open AccessTraction power systems for electrified railways: evolution, state of the art, and future trends
Traction power systems (TPSs) play a vital role in the operation of electrified railways. The transformation of conventional railway TPSs to novel structures is not only a trend to promote the development of e...
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Article
Open AccessElasticity-controlled jamming criticality in soft composite solids
Soft composite solids are made of inclusions dispersed within soft matrices. They are ubiquitous in nature and form the basis of many biological tissues. In the field of materials science, synthetic soft compo...
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Article
Open AccessLonidamine liposomes to enhance photodynamic and photothermal therapy of hepatocellular carcinoma by inhibiting glycolysis
Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has great promise in the treatment of cancer. However, there are many obstacles that can restrict the therapeutic efficacy of ...
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Article
Open AccessActivation of the human insulin receptor by non-insulin-related peptides
The human insulin receptor signalling system plays a critical role in glucose homeostasis. Insulin binding brings about extensive conformational change in the receptor extracellular region that in turn effects...
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Article
Open AccessscRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory
The tumor microenvironment (TME) in gastric cancer (GC) has been shown to be important for tumor control but the specific characteristics for GC are not fully appreciated. We generated an atlas of 166,533 cell...
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Article
Open AccessThe aphrodisiac potential of β-cyclodextrin–curcumin via stimulating cAMP-PKA pathway in testicular Leydig cells
The water-soluble β-cyclodextrin–curcumin (CDC) is used in pharmaceutical applications and as a natural food colorant. The previous study revealed that curcumin potentially impacted the reproductive system. Th...
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Article
Open AccessAnalysis of rail potential and stray current in MVDC railway electrification system
In contrast to the conventional direct current railway electrification system (DC-RES), the medium voltage direct current (MVDC)-RES is considered promising for long-distance high-speed corridors. In the MVDC-...
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Article
Open AccessMucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies
A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in ...
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Article
Open AccessA power-quality monitoring and assessment system for high-speed railways based on train-network-data center integration
In recent years, with the rapid development of high-speed railways (HSRs), power interruptions or disturbances in traction power supply systems have become increasingly dangerous. However, it is often impossib...
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Article
Open AccessModulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure
Following reverse transcription, HIV viral DNA is integrated into host cell genomes and establishes a stable latent infection, which has posed a major obstacle for obtaining a cure for HIV. HIV proviral transc...
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Article
Open AccessIL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice
The Zika virus (ZIKV) outbreak that occurred in multiple countries was linked to increased risk of nervous system injuries and congenital defects. However, host immunity- and immune-mediated pathogenesis in ZI...
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Article
Open AccessRationale and design of individualized quality improvement based on the Computer Analysing system to improve Stroke management quality Evaluation (CASE): a multicenter historically controlled study
Guideline-based medical care has been identified to improve outcomes in stroke. However, data acquisition and medical quality management during hospital stay still need to be improved in China. We have develop...
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Article
Open AccessMxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6
The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preven...
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Article
Open AccessQTL analysis for rice salinity tolerance and fine map** of a candidate locus qSL7 for shoot length under salt stress
Salinity is one of the major abiotic stresses limiting rice production worldwide. Understanding the genetic basis of salinity tolerance is key for rice breeding. In this study, a recombinant inbred line (RIL) ...
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Article
Open AccessAdaptive droop control for better current-sharing in VSC-based MVDC railway electrification system
The share of voltage source converter (VSC) technology is increasing in conventional power systems, and it is penetrating into specific transportation systems such as electric vehicles, railways, and ships. Re...
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Article
Open AccessA 3-bp deletion of WLS5 gene leads to weak growth and early leaf senescence in rice
In rice (Oryza sativa) and other grains, weak growth (dwarfism, short panicle length, and low seed-setting rate) and early senescence lead to reduced yield. The molecular mechanisms behind these processes have be...
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Article
Open AccessGenetic analysis and fine-map** of a new rice mutant, white and lesion mimic leaf1
Rice (Oryza sativa L.) leaf color mutants are excellent models for studying chlorophyll biosynthesis and chloroplast development. In this study, we isolated a stable genetic white and lesion mimic leaf1 (wlml1) m...
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Article
Open AccessA Class II small heat shock protein OsHsp18.0 plays positive roles in both biotic and abiotic defense responses in rice
Bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most devastating diseases of rice. However, the molecular mechanism underpinning the Xoo resistance of rice is still not fully understo...
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Article
Expression of HIV-encoded microRNA-TAR and its inhibitory effect on viral replication in human primary macrophages
A number of virus-encoded microRNAs have been shown to play important roles in virus replication and virus-host interactions, although the expression and function of miR-TAR-3p derived from the human immunodef...
