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Article
Open AccessCorrelation between newborn weight and serum BCAAs in pregnant women with diabetes
Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids for mammals. Maternal BCAAs during pregnancy have been associated with newborn development. Meanwhile, B...
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Article
The Role of Branched-chain Amino Acids and Their Metabolism in Cardiovascular Diseases
Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids for protein synthesis. Recent studies have yielded new insights into their diverse physiological and pat...
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Article
Targeting BCAA metabolism to potentiate metformin’s therapeutic efficacy in the treatment of diabetes in mice
An increasing body of evidence has shown that the catabolism of branched-chain amino acids (BCAAs; leucine, isoleucine and valine) is impaired in obese animals and humans, contributing to the development of in...
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Article
Open AccessSingle-cell Mayo Map (scMayoMap): an easy-to-use tool for cell type annotation in single-cell RNA-sequencing data analysis
Single-cell RNA-sequencing (scRNA-seq) has become a widely used tool for both basic and translational biomedical research. In scRNA-seq data analysis, cell type annotation is an essential but challenging step....
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Article
A blockchain-based access control protocol for secure resource sharing with mobile edge-cloud collaboration
The application scenarios of edge-cloud collaboration are very wide. In order to ensure the operational security of resource sharing among intelligent terminals in edge-cloud collaboration scenarios, and preve...
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Article
Open AccessCell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice
Parallel to major changes in fatty acid and glucose metabolism, defect in branched-chain amino acid (BCAA) catabolism has also been recognized as a metabolic hallmark and potential therapeutic target for heart...
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Article
Open AccessPreoperative administration of branched-chain amino acids reduces postoperative insulin resistance in rats by reducing liver gluconeogenesis
Postoperative insulin resistance (PIR) represents an important characteristic of metabolic response following surgical injury. Clinical outcomes are negatively correlated to postoperative insulin resistance an...
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Article
Open AccessA randomized controlled trial of the effects of whole grains versus refined grains diets on the microbiome in pregnancy
Dietary whole grain consumption has been postulated to have metabolic benefits. The purpose of this study was to compare a pregnancy diet containing 75% of total carbohydrates as refined grains with a diet of ...
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Article
Open AccessGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and...
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Chapter and Conference Paper
Energy-Aware Flow Table Strategy for Software Defined Wireless Power Communication Network Using Floyd Algorithm
With the continuous expansion of the services and the coverage of power telecommunication network, the reliability and flexibility of the network have been put forward higher requirements. In the power system,...
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Article
Layer Hall effect in a 2D topological axion antiferromagnet
Whereas ferromagnets have been known and used for millennia, antiferromagnets were only discovered in the 1930s1. At large scale, because of the absence of global magnetization, antiferromagnets may seem to behav...
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Chapter and Conference Paper
Energy-Aware Dynamic Cache Distribution Policy for Software Defined Mobile Edge Networks Using Ant-Q Learning
Deploying edge caching ability can significantly reduce the traffic volumes between edge networks and cloud, so as to save energy. However, how to intelligently use the communicating and caching capabilities o...
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Chapter and Conference Paper
EviDR: Evidence-Emphasized Discrete Reasoning for Reasoning Machine Reading Comprehension
Reasoning machine reading comprehension (R-MRC) aims to answer complex questions that require discrete reasoning based on text. To support discrete reasoning, evidence, typically the concise textual fragments ...
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Article
A new branch connecting thermogenesis and diabetes
Systemic accumulation of branched-chain amino acids (BCAAs) is a major metabolic hallmark and contributor to insulin resistance associated with obesity. A recent report identifies SLC25A44 as the BCAA transpor...
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Article
Open Access1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses
Reference genomes are essential for metagenomic analyses and functional characterization of the human gut microbiota. We present the Culturable Genome Reference (CGR), a collection of 1,520 nonredundant, high-...
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Article
Recovery succession drives the convergence, and grazing versus fencing drives the divergence of plant and soil N/P stoichiometry in a semiarid steppe of Inner Mongolia
Understanding the plant and soil elemental stoichiometry during grassland dynamics is important for develo** measures to enhance the restoration of degraded grassland. A number of restoration practices have ...
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Article
Parametric study of pyrolysis and steam gasification of rice straw in presence of K2CO3
A parametric study of pyrolysis and steam gasification of rice straw (RS) was performed to investigate the effect of the presence of K2CO3 on the behavior of gas evolution, gas component distribution, pyrolysis/g...
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Article
Regulatory mechanism of the three-component system HptRSA in glucose-6-phosphate uptake in Staphylococcus aureus
Glucose-6-phosphate (G6P) is a common alternative carbon source for various bacteria, and its uptake usually relies on the hexose phosphate antiporter UhpT. In the human pathogenic bacterium Staphylococcus aureus
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Article
Open AccessIdentification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose
Transcription factor carbohydrate responsive element binding protein (ChREBP) promotes glycolysis and lipogenesis in metabolic tissues and cancer cells. ChREBP-α and ChREBP-β, two isoforms of ChREBP transcribe...
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Article
ArtR, a novel sRNA of Staphylococcus aureus, regulates α-toxin expression by targeting the 5′ UTR of sarT mRNA
Recent studies point to the importance of small-noncoding RNAs (sRNAs) in bacterial virulence control. In Staphylococcus aureus, functional dissections of sRNAs are limited to RNA III, SprD, RsaE, SprA1, and SSR4...
