30 Result(s)

Article

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...

Mengqi Li, Yu Wang, **aoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu… in Cell Research (2024)

Article

Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis

Targeting ferroptosis has been identified as a promising approach for the development of cancer therapies. Monounsaturated fatty acid (MUFA) is a type of lipid that plays a crucial role in inhibiting ferropto...

Yanmei Yuan, Junting Xu, Quanxin Jiang… in Journal of Experimental & Clinical Cancer … (2024)

Article

Integrated proteogenomic and metabolomic characterization of papillary thyroid cancer with different recurrence risks

Although papillary thyroid cancer (PTC) has a good prognosis, its recurrence rate is high and remains a core concern in the clinic. Molecular factors contributing to different recurrence risks (RRs) remain poo...

Ning Qu, Di Chen, Ben Ma, Lijun Zhang, Qiu** Wang, Yuting Wang… in Nature Communications (2024)

Article

KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC

Immunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an immuno-suppressive effect to protect cancer cells from immun...

**ghan Li, Daiwang Shi, Siyi Li, **ang Shi, Yu Liu, Yi Zhang… in Cell Death & Disease (2024)

Article

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in co...

Yu-Qing Wu, Chen-Song Zhang, **ye **ong, Dong-Qi Cai, Chen-Zhe Wang… in Cell Research (2023)

Article

Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities

Integrins are transmembrane receptors that possess distinct ligand-binding specificities in the extracellular domain and signaling properties in the cytoplasmic domain. While most integrins have a short cytopl...

Siyi Li, Chibuzo Sampson, Changhao Liu, Hai-long Piao… in Cell Communication and Signaling (2023)

Article

Multidirectional characterization of cellular composition and spatial architecture in human multiple primary lung cancers

Multiple primary lung cancers (MPLCs) pose diagnostic and therapeutic challenges in clinic. Here, we orchestrated the cellular and spatial architecture of MPLCs by combining single-cell RNA-sequencing and spat...

Yawei Wang, Di Chen, Yu Liu, Daiwang Shi, Chao Duan, **ghan Li… in Cell Death & Disease (2023)

Article

Correction to: An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases

Di Chen, Zhen Ning, Huan Chen, Chang Lu, **aolong Liu, Tian **a, Huan Qi… in Oncogene (2022)

Article

Identification of serum metabolites enhancing inflammatory responses in COVID-19

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by a strong production of inflammatory cytokines such as TNF and IL-6, which underl...

Chen-Song Zhang, Bingchang Zhang, Mengqi Li, **aoyan Wei… in Science China Life Sciences (2022)

Article

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not ...

Chen-Song Zhang, Mengqi Li, Yu Wang, **aoyang Li, Yue Zong… in Nature Metabolism (2022)

Article

Publisher Correction: Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Fangzhou Liu, Tian Tian, Zhen Zhang, Shanshan **e, Jiecheng Yang… in Nature Metabolism (2022)

Article

Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex

Midkine (MDK), a secreted growth factor, regulates signal transduction and cancer progression by interacting with receptors, and it can be internalized into the cytoplasm by endocytosis. However, its intracell...

Tian **a, Di Chen, **aolong Liu, Huan Qi, Wen Wang, Huan Chen… in Cell Death & Disease (2022)

Article

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma

Elevated de novo lipogenesis is considered to be a crucial factor in hepatocellular carcinoma (HCC) development. Herein, we identify ubiquitin-specific protease 22 (USP22) as a key regulator for de novo fatty ...

Zhen Ning, **n Guo, **aolong Liu, Chang Lu, Aman Wang… in Nature Communications (2022)

Article

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects^1–4. For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role ...

Teng Ma, **ao Tian, Baoding Zhang, Mengqi Li, Yu Wang, Chunyan Yang, Jianfeng Wu… in Nature (2022)

Article

Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

Mengqi Li, Chen-Song Zhang, **-Wei Feng, **aoyan Wei, Cixiong Zhang… in Cell Research (2021)