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Article
Preparation of methoxy poly(ethyleneglycol)-block-poly(caprolactone) via activated monomer mechanism and examination of micellar characterization
The polymerization of ε–caprolactone (CL) in the presence of HCl·Et2O via activated monomer mechanism was performed to synthesize diblock copolymers composed of methoxy polyethyleneglycol (MPEG) and poly(ε–caprol...
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Article
Chondrogenic differentiation of bone marrow stromal cells in transforming growth factor-β1 loaded alginate bead
We developed alginate beads loaded with transforming growth factor-β1 (TGF-β1) to examine the possible application of the scaffold and cytokine carrier in tissue engineering. In this study, bone marrow stromal ce...
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Article
Surface and chemical properties of surface-modified UHMWPE powder and mechanical and thermal properties of its impregnated PMMA bone cement V. Effect of silane coupling agent on the surface modification of UHMWPE powder
Conventional poly(methyl methacrylate)(PMMA) bone cement has been widely used as an useful biopolymeric material to fix bone using artificial prostheses. However, many patients had to be reoperated, due to the...
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Article
The effect of gamma irradiation on PLGA and release behavior of BCNU from PLGA wafer
The objectives of this study were to investigate the influence of gamma irradiation for sterilization on poly(D,L-lactide-co-glycolide) (PLGA) with different molecular weight and the effect of gamma irradiation o...
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Article
Controlled release of nerve growth factor from sandwiched poly(L-lactide-co-glycolide) films for the application in neural tissue engineering
In order to fabricate new sustained delivery device of nerve growth factor (NGF), we developed NGFloaded biodegradable poly(L-lactide-co-glycolide) (PLGA, the mole ratio of lactide to glycolide 75∶25, molecular w...
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Article
Local drug delivery system using biodegradable polymers
For last five years, we are develo** the novel local drug delivery devices using biodegradable polymers, especially polylactide (PLA) and poly(D,L-lactide-co-glycolide) (PLGA) due to its relatively good biocomp...
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Article
Preparation of 5-fluorouracil-loaded poly(L-lactide-co-glycolide) wafer and evaluation ofin vitro release behavior
The controlled delivery of anticancer agents using biodegradable polymeric implant has been developed to solve the problem of penetration of blood brain barrier and severe systemic toxicity. This study was per...
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Article
Evaluation ofin vitro release profiles of fentanyl-loaded PLGA oligomer microspheres
In order to the development of the delivery device of long-acting local anesthetics for postoperative analgesia and control of chronic pain of cancer patient, fentanyl-loaded poly(l-lactide-co-glycolide)|(PLGA, m...
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Article
Preparation and characterization of small intestine submucosa powder impregnated poly(L-lactide) scaffolds: the application for tissue engineered bone and cartilage
In order to endow with new bioactive functionality from small intestine submucosa (SIS) powder as natural source to poly(L-lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) synthetic biodegradable polymer, por...
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Article
Effect of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) surface with different wettability on fibroblast behavior
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a microbial storage polymer with biodegradable properties. In order to improve the cell compatibility of PHBV surfaces, the physicochemical treatments have b...
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Chapter
Cell Behavior on Polymer Surfaces with Different Functional Groups
Recently a large number of research groups have studied the interaction of biomedical materials with cultured cells because cell-compatible materials are thought to be very important to many biomedical applica...
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Chapter and Conference Paper
Cell Adhesion and Protein Adsorption on Gradient Surfaces
A new method for preparing a wettability gradient on polymer surfaces was developed. Low density polyethylene sheets were treated in air with corona from a knife-type electrode whose power gradually increases ...