5 Result(s)
within
H.-J. Merker
Biomedicine, general
Pharmacology/Toxicology
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Article
Quinolone-induced arthropathy: exposure of magnesium-deficient aged rats or immature rats, mineral concentrations in target tissues and pharmacokinetics
Quinolone treatment or magnesium deficiency induce identical cartilage lesions in juvenile rats and show additive arthropathogenic effects. It has been shown previously that neither condition is arthropathoge...
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Article
Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats
Recently, we showed that magnesium deficiency induces lesions in knee joint cartilage from 5-week-old rats that are very similar to ofloxacin-induced cartilage defects. We concluded that quinolone-induced art...
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Article
Ofloxacin in juvenile non-human primates and rats. Arthropathia and drug plasma concentrations
Arthropathia in juvenile animals is the most important toxic effect induced by quinolones. We conducted pharmacokinetic and morphological studies with ofloxacin on non-human primates (Callithrix jacchus, Marmoset...
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Article
Influence of 13-cis and all- trans retinoic acid on rat embryonic development in vitro: correlation with isomerisation and drug transfer to the embryo
In vitro experiments using whole rat embryo cultures show that all -trans retinoic acid (all- trans RA) administered at low concentrations (30 ng/ml culture medium) is 10 times more active than 13-cis retinoic ac...
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Article
An improved method for the preparation of human fetal and adult hepatocytes
A method to prepare isolated hepatocytes from the small amounts of liver or liver fragments obtained from the human fetus following therapeutic abortion in early pregnancy is described. The hepatocytes have be...
