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Article
Biochemical studies on the nucleic acid metabolism of embryonic tissue and the effect of drugs
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Article
Effect of benzo(α)pyrene treatment on the benzo(α)pyrene hydroxylase activity in maternal liver, placenta, and fetus of the rat during day 13 to day 18 of gestation
Pregnant rats were treated with an oral dose of 40.0 mg benzo(α) pyrene (BP) per kg body weight and were sacrificed 24 h later. Maternal liver, placenta, and fetus were assayed for BP-hydroxylase activity. The...
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Article
Studies on the teratogenic phase specificity of actinomycin D in the rat
In order to elucidate the phase specificity of the embryo-lethal and teratogenic action of actinomycin D (day 5–10 of gestation) rats received 3H-actinomycin D at different times of gestation. The distribution of...
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Article
Growth kinetics of mammalian embryos during the stage of differentiation
In order to get insight into the synthesis rates occuring in mammalian embryos during the phase of differentiation, wet and dry weight as well as DNA-, RNA-, and nitrogen content of the whole implantation site...
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Article
Effect of cyclophosphamide pretreatment of pregnant animals on the activity of nuclear DNA-dependent RNA-polymerases in different parts of rat embryos
On day 13+0 h of gestation rats received 10 mg/kg cyclophosphamide i.p. 3, 9, and 24 h after administration of the drug the activities of the DNA-dependent RNA polymerase reactions were measured in the whole e...
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Article
Benzo(a)pyrene hydroxylase activity in the whole implantation site, decidua, placenta and fetal membranes of the rat
Treatment of pregnant rats with 40 mg benzo(a)pyrene (BP) per kg body weight p.o. 24 h prior to sacrifice results in an induction of BP hydroxylase activity in the whole implantation site, the decidua, the pla...
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Article
The effect of d-penicillamine of the skeletal development of rat foetuses
Rats received 20, 50 or 100mg/animal d-penicillamine i. p. twice daily on days 15, 16, 17, 18 and 19 of gestation, i. e. a total dose of 200, 500 resp. 1000 mg/animal. At all dosages the number of fetal resorptio...
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Chapter and Conference Paper
Production and Formation of the Basal Lamina
The chemical composition of the basal lamina (BL), its morphology, localization and behaviour under experimental and pathological conditions have been investigated extensively over the last few years (Hawkes a...
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Chapter and Conference Paper
Cell-Matrix Interaction in the Differentiation of the Intestinal Epithelium
Epithelio-mesenchymal interactions are a prerequisite for the normal cytodifferentiation of all epithelial tissues during ontogenesis. Whereas the pioneering investigators reported on the necessity of the mere...
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Article
The basement membrane of the persisting maternal blood vessels in the placenta of Callithrix jacchus
Formation and morphology of the thickened basement membrane-like layer around the persisting maternal vessels of the Callithrix jacchus placenta were investigated from day 45 until term (day 142) using light, ...
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Article
Ultrastructural and histochemical characterization of marmoset (Callithrix jacchus) Leydig cells during postnatal development
Leydig cell development was investigated in the marmoset (Callithrix jacchus) testis from 24 h post partum (pp) up to sexual maturity, using ultrastructural and histochemical methods.