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Article
Structure and specificity of a permissive bacterial C-prenyltransferase
Discovery and characterization of an unusually permissive C-prenyltransferase provides a biocatalytic route for generating novel prenylated compounds, including daptomycin derivatives with increased potency. ...
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Article
Identification of a farnesol analog as a Ras function inhibitor using both an in vivo Ras activation sensor and a phenotypic screening approach
Mutations in Ras isoforms such as K-Ras, N-Ras, and H-Ras contribute to roughly 85, 15, and 1 % of human cancers, respectively. Proper membrane targeting of these Ras isoforms, a prerequisite for Ras activity,...
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Article
Modulation of anthracycline-induced cytotoxicity by targeting the prenylated proteome in myeloid leukemia cells
Deregulation of Ras/ERK signaling in myeloid leukemias makes this pathway an interesting target for drug development. Myeloid leukemia cell lines were screened for idarubicin-induced apoptosis, cell-cycle prog...
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Protocol
The Metabolic Labeling and Analysis of Isoprenylated Proteins
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Article
Interproton distance bounds from 2D NOE intensities: Effect of experimental noise and peak integration errors
The effect of experimental and integration errors on the calculations in interproton distances from NOE intensities is examined. It is shown that NOE intensity errors can have a large impact on the distances d...
