Skip to main content

3 Result(s)

within Fredrick O. Onono Remove this filter

and

  1. No Access

    Chapter

    Phospholipase D and Choline Metabolism

    Phospholipases D (PLDs) catalyze hydrolysis of the diester bond of phospholipids to generate phosphatidic acid and the free lipid headgroup. In mammals, PLD enzymes comprise the intracellular enzymes PLD1 and ...

    Fredrick O. Onono, Andrew J. Morris in Lipid Signaling in Human Diseases (2020)

  2. No Access

    Article

    Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia

    Transforming mutations in RAS genes are commonly found in human malignancies, including myeloid leukemias. To investigate the incidence, spectrum, and distribution of activating K- and N-RAS mutations in cytogene...

    Christoph W. M. Reuter, Jürgen Krauter, Fredrick O. Onono… in Annals of Hematology (2014)

  3. No Access

    Article

    Modulation of anthracycline-induced cytotoxicity by targeting the prenylated proteome in myeloid leukemia cells

    Deregulation of Ras/ERK signaling in myeloid leukemias makes this pathway an interesting target for drug development. Myeloid leukemia cell lines were screened for idarubicin-induced apoptosis, cell-cycle prog...

    Michael A. Morgan, Fredrick O. Onono, H. Peter Spielmann… in Journal of Molecular Medicine (2012)