9 Result(s)
within
H. L. Tan
Medical Education
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Article
Open AccessRationale and design of the PHOspholamban RElated CArdiomyopathy intervention STudy (i-PHORECAST)
The p.Arg14del (c.40_42delAGA) phospholamban (PLN) pathogenic variant is a founder mutation that causes dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM). Carriers are at increased risk of m...
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Article
Open AccessPatient perspectives on priorities for research on conventional and sex- and gender-related cardiovascular risk factors
Recently, cardiovascular disease (CVD) research has focused on sex- and gender-related cardiovascular risk factors, in addition to conventional risk factors. This raises the question which factors are perceive...
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Article
Open AccessAtrial fibrillation mimicking ventricular fibrillation confuses an automated external defibrillator
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Article
Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome
The risk for lethal ventricular arrhythmias is increased in individuals who carry mutations in genes that encode cardiac ion channels. Loss-of-function mutations in SCN5A, the gene encoding the cardiac sodium cha...
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Article
Pregnancy and the risk of torsades de pointes in congenital long-QT syndrome
Patients with congenital long-QT syndrome (LQTS) are at increased risk of ventricular arrhythmias during stressful situations. Large-scale studies have pointed out that affected individuals are particularly at...
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Article
Short-coupled variant of torsade de pointes
A 36-year-old man with a history of primary sclerosing cholangitis and epilepsy was admitted to our hospital for cholangitis. During admission he was resuscitated because of ventricular fibrillation. ECGs show...
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Article
Left superior vena cava, a remnant of embryological development
A 46-year-old Brugada syndrome patient underwent insertion of a dual-chamber implantable cardioverter- defibrillator (ICD), revealing a left-sided superior vena cava (SVC), (figure 1), running, characteristica...
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Article
Gender disparities in torsade de pointes ventricular tachycardia
Background Gender disparities in the incidence of torsade de pointes (TdP) ventricular tachycardia exist, but the mechanisms in humans are unresolved. We addressed this issue using a mathematical model of a human...
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Article
Biological pacing by gene and cell therapy
At present, cardiac rhythm disorders such as sick sinus syndrome (SSS) or AV nodal block (AVB) are usually treated by electronic pacemakers. These devices have significant shortcomings, including lack of auton...
